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Pollutant Altered Allergic Responses

This study has been completed.
Information provided by:
National Institute of Environmental Health Sciences (NIEHS) Identifier:
First received: February 20, 2001
Last updated: March 22, 2006
Last verified: March 2006
This study is designed to investigate whether exposure to particulate air pollution increases the allergic response to allergens. Research studies suggest that symptoms in individuals with allergies may be aggravated by exposure to particulate air pollution. We sought to experimental determine this by exposing human volunteers to combustion particles, a component of air pollution, and then challenge them with an allergen such as ragweed or oak tree pollen. Using biological tests we can measure whether the allergen response is magnified by prior particulate exposure.

Allergic Rhinitis Allergy

Study Type: Observational
Study Design: Allocation: Random Sample
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Markers of Pollutant Altered Allergic Responses

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Estimated Enrollment: 20
Study Start Date: December 1998
Estimated Study Completion Date: August 2002
Detailed Description:
To study whether particulates enhance the allergic response, we chose the upper airway as a model of allergic inflammation and nasal lavage as a non-invasive method for obtaining samples. The nasal cavity is both an excellent model of allergic inflammation and provides an easily accessible site for study. We measured inflammatory cells and cytokines in the nasal lavage fluid. Our specific hypothesis was that particulate exposure prior to allergen challenge would enhance inflammatory cell recruitment and expression of inflammatory cytokines.

Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Adult without a history of asthma or respiratory disease.
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Please refer to this study by its identifier: NCT00011440

United States, Massachusetts
Harvard School of Public Health
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
National Institute of Environmental Health Sciences (NIEHS)
  More Information Identifier: NCT00011440     History of Changes
Other Study ID Numbers: 8077-CP-001
Study First Received: February 20, 2001
Last Updated: March 22, 2006

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):
Air pollution
Lung function

Additional relevant MeSH terms:
Rhinitis, Allergic
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases processed this record on August 18, 2017