Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency

This study has been completed.
Information provided by:
National Center for Research Resources (NCRR) Identifier:
First received: February 12, 2001
Last updated: June 23, 2005
Last verified: December 2003
The etiology of immune-mediated diabetes mellitus (IMD) remains unclear. However, previous studies indicate that autoimmunity may be a result of dysfunction of natural killer T cells (NK-T cells). Newly diagnoses patients with IMD have been shown in our laboratory to have significantly lower NK-T cells than normal controls. Other studies have shown that oral administration of lactobacillus can boost NK-T cell activity in children with HIV without side effects. Our objective is to evaluate the effect of lactobacillus administration on NK-T cell activity in patients with IMD

Condition Intervention
Diabetes Mellitus
Drug: Oral lactobacillus administration

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Lactobacillus Plantarum as Therapy for NK-T Cell Deficiency

Resource links provided by NLM:

Further study details as provided by National Center for Research Resources (NCRR):


Ages Eligible for Study:   1 Year to 95 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Recently diagnosed (within the last 6 months) patients with immune-mediated (type 1) diabetes
  Contacts and Locations
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Please refer to this study by its identifier: NCT00011141

United States, New York
Cornell University
New York, New York, United States, 10021
Sponsors and Collaborators
National Center for Research Resources (NCRR)
  More Information

No publications provided Identifier: NCT00011141     History of Changes
Other Study ID Numbers: NCRR-M01RR06020-0165
Study First Received: February 12, 2001
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):
Immune-mediated diabetes mellitus

Additional relevant MeSH terms:
Diabetes Mellitus
Endocrine System Diseases
Glucose Metabolism Disorders
Metabolic Diseases processed this record on November 27, 2015