This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Effects of Meditation on Mechanism of Coronary Heart Disease

This study has been completed.
Information provided by:
National Center for Complementary and Integrative Health (NCCIH) Identifier:
First received: February 2, 2001
Last updated: August 17, 2006
Last verified: July 2006
To study the effects of Transcendental Meditation on Coronary Heart Disease

Condition Intervention Phase
Coronary Heart Disease Procedure: Meditation Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Primary Purpose: Treatment
Official Title: Effects of Meditation on Mechanism of Coronary Heart Disease

Resource links provided by NLM:

Further study details as provided by National Center for Complementary and Integrative Health (NCCIH):

Estimated Enrollment: 145
Study Start Date: September 1999
Estimated Study Completion Date: August 2002
Detailed Description:
Recent advances in our understanding of the pathophysiology of acute cardiac events - specifically, identification of the roles that arterial vasomotor dysfunction and autonomic nervous system imbalances play in the pathophysiologic cascade during such acute events - provides a platform for new mechanistic investigation of the interplay of psychosomatic stress and CHD (coronary heart disease). Preliminary evidence further suggests that Complementary and Alternative Medicine (CAM) practices, such as the Transcendental Meditation (TM) technique, can not only reduce stress but also reduce acute cardiac events in patients with CHD. Based on these and related data, we propose a randomized, blinded, controlled study of the effects of one CAM practice, the TM technique, compared to a control group, on the primary outcomes of (1) arterial vasomotor dysfunction (brachial artery reactivity); (2) autonomic nervous system imbalances (heart rate variability); (3) transient myocardial ischemia (ST-segment depression); and (4) the secondary outcomes of psychological stress and quality of life (anger, hostility, anxiety, depression, perceived health, disease-specific symptoms, and life stress/social resources).

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Able to attend training sessions and meetings
  • Local residence

Exclusion Criteria:

  • Comorbid disease precluding survival in group
  • MI, unstable angina, CABG or PTCA within last three months.
  • Cognitive/psychological/substance abuse impairment
  • Atrial fibrillation, predominant pacemaker rhythm or significant conduction system disease
  • Significant valvular heart disease
  • Class III or IV heart failure
  • Renal failure
  • Participating in a formal stress management program
  • Participation in another trial
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00010738

United States, California
Preventive and Rehabilitative Cardiac Center
Los Angeles, California, United States
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
Principal Investigator: C. Noel Bairey Merz, M.D. Preventive and Rehabilitative Cardiac Center
  More Information Identifier: NCT00010738     History of Changes
Obsolete Identifiers: NCT00009399
Other Study ID Numbers: R01 AT000226-01M
R01AT000226-01 ( US NIH Grant/Contract Award Number )
Study First Received: February 2, 2001
Last Updated: August 17, 2006

Additional relevant MeSH terms:
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases processed this record on June 23, 2017