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Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00010530
First Posted: February 5, 2001
Last Update Posted: December 7, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Center for Complementary and Integrative Health (NCCIH)
  Purpose
The purpose of this study is to evaluate the effects of meditation on older African Americans with documented cardiovascular disease (CVD).

Condition Intervention Phase
Cardiovascular Diseases Procedure: Meditation Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Single
Primary Purpose: Treatment
Official Title: Basic Mechanisms of Meditation and Cardiovascular Disease in Older Blacks

Resource links provided by NLM:


Further study details as provided by National Center for Complementary and Integrative Health (NCCIH):

Study Start Date: September 1999
Study Completion Date: July 2006
Primary Completion Date: July 2006 (Final data collection date for primary outcome measure)
Detailed Description:
Cardiovascular disease (CVD) is the leading cause of death and disability in older African Americans, and accounts for 40% of the disproportionate risk for mortality observed in African Americans compared to white Americans. The majority of CVD patients experience acute cardiac events, many sudden and unexpected, despite conventional treatment of their disease and associated traditional risk factors. The pathophysiologic basis of these cardiac events is not fully established, but substantial evidence indicates that psychosocial stress and the sympathetic nervous system have adverse effects on both vasomotor function and long-term autonomic balance. Recent advances in the understanding of the pathophysiology of acute cardiac events-specifically, the roles that arterial vasomotor dysfunction and sympathetic nervous system imbalance play in the pathophysiology of such acute events-provide a platform for a new mechanistic investigation of the interplay of psychosocial and environmental stress and CVD. Preliminary evidence demonstrating elevated peripheral vasoconstriction due to stress-mediated sympathetic nervous system response in African Americans further suggests that these mechanisms are particularly relevant in this group.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • African-American (self-identified)
  • Local residence
  • Able to participate
  • Coronary artery disease by MI, CABG, PTCA (>3 months prior), or angiography
  • Consent and referring MD approval
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00010530


Locations
United States, California
Charles R. Drew University of Medicine and Science
Los Angeles, California, United States
United States, Iowa
Maharishi University of Management Center for Health and Aging Studies
Fairfield, Iowa, United States, 52557
Sponsors and Collaborators
National Center for Complementary and Integrative Health (NCCIH)
Investigators
Principal Investigator: Robert H. Schneider, MD Center for Health and Aging Studies
  More Information

ClinicalTrials.gov Identifier: NCT00010530     History of Changes
Obsolete Identifiers: NCT00009087
Other Study ID Numbers: P50AT000082-01P1 ( U.S. NIH Grant/Contract )
P50AT000082-01 ( U.S. NIH Grant/Contract )
P50AT000082-02 ( U.S. NIH Grant/Contract )
First Submitted: February 2, 2001
First Posted: February 5, 2001
Last Update Posted: December 7, 2009
Last Verified: December 2009

Keywords provided by National Center for Complementary and Integrative Health (NCCIH):
CVD

Additional relevant MeSH terms:
Cardiovascular Diseases