Genetic Analysis of Familial Keloids
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|ClinicalTrials.gov Identifier: NCT00008502|
Recruitment Status : Completed
First Posted : January 15, 2001
Last Update Posted : December 9, 2019
The purpose of this study is to identify the gene or genes responsible for keloid formation. Keloids are raised scars on the skin that form after a minor injury. A tendency to develop keloids often runs in families, suggesting a possible genetic basis.
People who have had a classic (butterfly-shaped or wound-overflowing) keloid for at least one year may be eligible for this study. In addition to these probands (original participants), family members over 12 years of age who have either classic or non-classic keloids and those 18 years of age or older without keloids may participate.
Probands and family members with keloids will have a medical history focusing on skin problems-particularly keloids-and a skin examination. In some cases, with the subject s permission, photos of the keloids will be taken. All participants will have 35 milliliters (about 2 tablespoons) of blood drawn for DNA (genetic) testing and for measurement of blood proteins, including cytokines, which can affect other tissues and cause scarring. Part of the blood sample will be used for additional genetic studies unrelated to keloids. The samples will be coded for confidentiality.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||106 participants|
|Official Title:||Genetic Analysis of Familial Keloids|
|Actual Study Start Date :||August 14, 2001|
18 years of age or older
family members over 12 years of age
who have either classic or non-classic keloids
original participants who have had a classic (butterfly-shaped or wound-overflowing) keloidfor at least one year
- Finding a genetic locus [ Time Frame: 12/01/2018 ]The purpose of this study is to identify the gene or genes responsible for keloid formation
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00008502
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Jeffrey B Kopp, M.D.||National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|