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Antibiotic Treatment of Gulf War Veterans' Illnesses

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00007735
Recruitment Status : Completed
First Posted : January 1, 2001
Last Update Posted : January 21, 2009
United States Department of Defense
Information provided by:
VA Office of Research and Development

Brief Summary:
In 1990 and 1991, the U.S. deployed approximately 700,000 troops to the Persian Gulf to liberate Kuwait from Iraqi occupation. While there were few casualties associated with the Gulf War, many individuals returned from this conflict with unexplained symptoms and illnesses. This constellation of symptoms has been termed Gulf War Veterans' Illnesses (GWI). Although several explanations have been offered as to the cause of GWI, none of the putative etiologic agents or conditions is currently supported by sufficient evidence. One explanation that has received fairly widespread attention is systemic Mycoplasma fermentans infection. It is the purpose of this study to determine if antibiotic treatment directed against Mycoplasma species (i.e. doxycycline) will improve functioning and symptoms in deployed Gulf War veterans with GWI.

Condition or disease Intervention/treatment Phase
Persian Gulf Syndrome Mycoplasma Infections Drug: Doxycycline (200mg/day) or Placebo Phase 3

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Study Type : Interventional  (Clinical Trial)
Enrollment : 450 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Official Title: CSP #475 - Persian Gulf - Antibiotic Treatment Trial of Gulf War Veterans' Illnesses
Study Start Date : January 1999
Study Completion Date : October 2001

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Antibiotics
Drug Information available for: Doxycycline

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
All veterans deployed to the Gulf War between August, 1990 and August, 1991 having at least two of the following symptoms: Fatigue, musculoskeletal pain or neurocognitive dysfunction. Mycoplasma positive

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00007735

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Sponsors and Collaborators
US Department of Veterans Affairs
United States Department of Defense
Layout table for additonal information Identifier: NCT00007735    
Other Study ID Numbers: 475
First Posted: January 1, 2001    Key Record Dates
Last Update Posted: January 21, 2009
Last Verified: February 2007
Keywords provided by VA Office of Research and Development:
antibiotic treatment
mycoplasma species
Gulf War Veterans' Illnesses (GWI)
mycoplasma positive
Gulf War Syndrome
Additional relevant MeSH terms:
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Mycoplasma Infections
Persian Gulf Syndrome
Lung Diseases
Respiratory Tract Diseases
Pleural Diseases
Respiratory Tract Infections
Mycoplasmatales Infections
Gram-Negative Bacterial Infections
Bacterial Infections
Occupational Diseases
Anti-Bacterial Agents
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents