Morphine Gel for Bedsores

This study has been completed.
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by:
University of Kansas Medical Center Identifier:
First received: December 16, 2000
Last updated: May 17, 2013
Last verified: May 2013

This study tests the effectiveness of a morphine-containing gel for reducing pain caused by pressure ulcers, also known as bedsores or pressure sores. We will apply the gel containing morphine, or the gel alone, directly onto painful pressure ulcers and compare the results.

Condition Intervention Phase
Decubitus Ulcer
Drug: Pain relief for pressure ulcers
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Morphine-Infused Gel for Pressure Ulcer Analgesia

Resource links provided by NLM:

Further study details as provided by University of Kansas Medical Center:

Estimated Enrollment: 75
Study Start Date: March 2000
Estimated Study Completion Date: February 2003
Detailed Description:

In this study, we will apply a morphine-containing gel (or placebo) directly onto painful pressure ulcers. We will take participants off of any opioid-containing medications upon entry into the study. This allows us to measure any morphine that may enter into the bloodstream from the topically applied gel.

The purpose of this study is to examine the efficacy of the gel for pressure ulcer analgesia, as well as the systemic absorption of morphine from the topically applied gel. We will document the amount of pain medications taken by participants to determine whether the gel decreases the need for these drugs.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Presence of a Stage II pressure ulcer.
  • Pressure ulcer must be painful.
  • Primary Care physician must approve participation.
  • Thinking ability must be clear and intact.
  • Willing to change pain medication to oxycodone.

Exclusion Criteria:

  • Allergy to morphine, oxycodone or intrasite gel.
  • Use of codeine- or morphine-containing medications.
  • Use of pain medications for anything other than the pressure ulcer.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00007254

United States, Kansas
The University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
United States, Missouri
Kindred Hospital
Kansas City, Missouri, United States
Sponsors and Collaborators
University of Kansas Medical Center
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Principal Investigator: Teresa D. Long, MD The University of Kansas Medical Center
  More Information

Publications: Identifier: NCT00007254     History of Changes
Other Study ID Numbers: R01 AR45506, R01AR045506, NIAMS-061
Study First Received: December 16, 2000
Last Updated: May 17, 2013
Health Authority: United States: Federal Government

Keywords provided by University of Kansas Medical Center:
Morphine gel
Pressure ulcer

Additional relevant MeSH terms:
Pressure Ulcer
Skin Diseases
Skin Ulcer
Analgesics, Opioid
Central Nervous System Agents
Central Nervous System Depressants
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sensory System Agents
Therapeutic Uses processed this record on October 09, 2015