Trends in Trans-Fatty Acid Intake Between 1980 and 1997

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: November 16, 2000
Last updated: June 23, 2005
Last verified: April 2004

To examine trends in trans-fatty acid intake by using newly available nutrient data to recalculate 24 dietary recalls from the Minnesota Heart Survey.

Cardiovascular Diseases
Coronary Disease
Heart Diseases

Study Type: Observational
Study Design: Observational Model: Defined Population

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: April 2000
Estimated Study Completion Date: March 2002
Detailed Description:


In recent years concern has arisen about the potential health hazards of trans-fatty acids in the American diet. Dietary intake of trans-fatty acids has been linked to unhealthy shifts in serum lipid profiles and to coronary heart disease (CHD) in a number of studies. Although several studies have estimated intakes of trans-fatty acids in U.S. populations, presently data is lacking regarding trends in intake of trans-fatty acids in the population. Furthermore, it is unclear how trends in intake of trans-fatty acids may be related to changes in other dietary and non-dietary CHD risk factors and CHD mortality.


The study used newly available nutrient data to recalculate dietary data collected as part of the Minnesota Heart Survey (MHS) to examine trends in intake of trans-fatty acids. The MHS was an ongoing observational epidemiologic study of trends in risk factors and cardiovascular morbidity and mortality among independent cross-sectional probability samples of the Minneapolis-St. Paul, Minnesota, metropolitan area. Surveys were conducted in 1980-1982, 1985-1987, 1990-1992 and 1995-1997. Diet was among the CVD risk factors measured as part of each survey. In this research, 24-hour dietary recalls collected from MHS participants were recalculated using an updated food and nutrient database that included trans-fatty acid values (16:1, 18:1, 18:2, and total). Intake estimates resulting from recalculation were analyzed to examine temporal trends in trans-fatty acid intake between 1980 and 1997, and to examine the relationship of temporal trends in trans-fatty acid intake to temporal changes in other dietary and non-dietary CHD risk factors and changes in CHD mortality. The MHS data provided a unique opportunity to examine a dietary constituent only recently recognized as a potential risk factor for CHD.


Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

No eligibility criteria

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Please refer to this study by its identifier: NCT00006500

Sponsors and Collaborators
Investigator: Lisa Harnack University of Minnesota - Clinical and Translational Science Institute
  More Information

Publications: Identifier: NCT00006500     History of Changes
Other Study ID Numbers: 941
Study First Received: November 16, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Arterial Occlusive Diseases
Heart Diseases
Myocardial Ischemia
Vascular Diseases processed this record on August 30, 2015