Hypertension in Black Americans: A Life Course Approach

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00006408
Recruitment Status : Completed
First Posted : October 13, 2000
Last Update Posted : March 28, 2014
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Duke University

Brief Summary:
To investigate the relationship between life-stress factors associated with socioeconomic conditions and hypertension.

Condition or disease
Cardiovascular Diseases Heart Diseases Hypertension

Detailed Description:


Increasingly, researchers are recognizing that risk for cardiovascular disease (CVD) in adulthood is rooted in the social and material life conditions of childhood, and that these childhood conditions may predict risk for CVD above and beyond traditional adulthood indicators of socioeconomic status (SES) such as education, occupation or income. Nowhere is this life course perspective on CVD risk more important than in the case of African Americans, especially the generation that "came of age" in the U.S. South in the late 1950s and 1960s, the peak years of the modern Civil Rights Movement. While some African American members of this age cohort were able to take advantage of the new opportunities for economic advancement, some others were not, resulting thereafter in different life course trajectories of exposure to social and economic hardship. The relationship between variations in these social and economic life course trajectories, and CVD risk (specifically hypertension) in adulthood, has not been investigated in African Americans.


The study uses the Pitt County, (NC) cohort, a community sample of African Americans (N=1784, 66 percent female, 80 percent response rate) who were between 25-50 years of age at baseline in 1988. Normotensives in the baseline sample were re-examined in 1993 (N=1195, 66 percent female, 85 percent response rate). In addition to measuring blood pressure, extensive data on psychosocial, behavioral, and anthropometric characteristics were obtained at both times. The study re-examines the original cohort in 2001; the anticipated sample size is 1142 individuals (717 women and 425 men). Starting from age 20, respondents' reported exposure to three domains of socioenvironmental stressors will be assessed: (1) adverse socioeconomic conditions; (2) low levels of social integration; and (3) racial discrimination. Taken individually, and then collectively, the greater the cumulative life course exposure to these stressors, the greater the risk for adult hypertension is expected to be. The primary analyses will focus on the relationship between pre-1988 exposures and 1988 blood pressure status (retrospective analyses), and the relationship between pre-1988 exposures and changes in blood pressure status between 1988 and 2001(prospective analyses).

Study Type : Observational
Time Perspective: Retrospective
Study Start Date : August 2000
Actual Primary Completion Date : January 2006
Actual Study Completion Date : January 2006

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00006408

Sponsors and Collaborators
Duke University
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Sherman James Duke University

Responsible Party: Duke University Identifier: NCT00006408     History of Changes
Other Study ID Numbers: 933
R01HL065645 ( U.S. NIH Grant/Contract )
First Posted: October 13, 2000    Key Record Dates
Last Update Posted: March 28, 2014
Last Verified: March 2014

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Vascular Diseases