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Angiotensin-Converting Enzyme Gene Polymorphism and the Risk of Chronic Allograft Nephropathy

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ClinicalTrials.gov Identifier: NCT00006328
Recruitment Status : Completed
First Posted : October 5, 2000
Last Update Posted : June 24, 2005
Information provided by:
National Center for Research Resources (NCRR)

Brief Summary:
This study is intended to help doctors learn about the relationships between specific genetic makeup (gene markers) and the development of chronic rejection. This study is being done to see if there is a relationship between genetic patterns and the development of Chronic Allograft Nephropathy (CAN). Medical scientists also hope to learn more about how genetic differences between people determine their response to a drug or a disease by storing a small blood sample in a special "bank". This sample may be tested at some point in the future in an attempt to better understand the factors that may influence rejection, transplantation outcomes and transplant success rates.

Condition or disease
Kidney Disease

Study Type : Observational
Observational Model: Natural History
Time Perspective: Retrospective

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Diseases
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All subjects must be recipients of a renal allograft.
  • Study subjects must have evidence of biopsy-proven Chronic Allograft Nephropathy (CAN).
  • Control subjects must not have evidence of CAN.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00006328

United States, Michigan
Univ. of Michigan Health System
Ann Arbor, Michigan, United States, 48109-0391,
Sponsors and Collaborators
National Center for Research Resources (NCRR)

ClinicalTrials.gov Identifier: NCT00006328     History of Changes
Other Study ID Numbers: NCRR-M01RR00042-1678
M01RR000042 ( U.S. NIH Grant/Contract )
First Posted: October 5, 2000    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 2003

Keywords provided by National Center for Research Resources (NCRR):
Chronic Allograft Nephropathy (CAN)
Transplantation immunology
Graft Rejection

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases