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The Relationship Between Vitamin D, Fingernail Thickness and Bone Density

This study has been completed.
Information provided by:
National Center for Research Resources (NCRR) Identifier:
First received: September 7, 2000
Last updated: June 23, 2005
Last verified: December 2003

Vitamin D deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population. An unknown number of elderly have vitamin D resistance resulting in a functional vitamin D deficiency state. Because there are no simple procedures or blood tests that identify vitamin D resistance, its prevalence and contribution to disability in the elderly is unknown. Our inability to screen for this condition precludes our ability to initiate and monitor treatment.

Previous studies indicate that fingernail thickness correlates with vitamin D status and may therefore provide a simple cost effective procedure to not only identify patients with vitamin D deficiency but also, those with vitamin D resistance. This procedure may also provide a way to monitor an individual's response to treatment.

This study is designed to demonstrate the association between fingernail thickness and vitamin D status.

Condition Intervention Phase
Osteoporosis Drug: Vitamin D Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Masking: Double
Primary Purpose: Diagnostic

Resource links provided by NLM:

Further study details as provided by National Center for Research Resources (NCRR):


Ages Eligible for Study:   25 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • females 25-75 years of age with no known bone disorders

Exclusion Criteria:

  • history of vertebral fractures or nonvertebral fractures without trauma
  • prescription medications for prevention of osteoporosis (including vitamin D other than multivitamin and estrogen)
  • history of malignancy other than basal cell or squamous cell cancer of the skin
  • use of steroids or anticonvulsants in the 6 months prior to enrollment
  Contacts and Locations
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Please refer to this study by its identifier: NCT00006196

United States, Missouri
4488 Forest Park, Suite 201
St. Louis, Missouri, United States, 63108
Sponsors and Collaborators
National Center for Research Resources (NCRR)
  More Information Identifier: NCT00006196     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0754
M01RR000036 ( U.S. NIH Grant/Contract )
Study First Received: September 7, 2000
Last Updated: June 23, 2005

Keywords provided by National Center for Research Resources (NCRR):
Vitamin D resistance

Additional relevant MeSH terms:
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Vitamin D
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents processed this record on August 18, 2017