Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00006194
Recruitment Status : Completed
First Posted : September 8, 2000
Last Update Posted : June 24, 2005
Information provided by:
National Center for Research Resources (NCRR)

Brief Summary:
Decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline. The declines in muscle mass associated with aging may be related to alterations in specific kinds of growth factors in the muscle. Elderly hip fracture patients often have significant decreases in muscle mass. The purpose of this study is to investigate whether an exercise program can induce changes in muscle growth factors that are associated with increases in muscle mass and strength in elderly hip fracture patients.

Condition or disease Intervention/treatment Phase
Hip Fractures Muscular Atrophy Behavioral: Exercise Not Applicable

Study Type : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Single Group Assignment
Primary Purpose: Treatment

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U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Enrollment in HSC protocol #97-0695 "Rehabilitation Intensification Post Hip Fracture"
  • Community-dwelling
  • Hip fracture within 16 weeks of the screening assessment for protocol 97-0695
  • Persistent mobility and/or ADL impairments, but independent in ambulation
  • Modified Physical Performance Test (PPT) score between 12 and 28

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00006194

United States, Missouri
Washington University
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
National Center for Research Resources (NCRR) Identifier: NCT00006194     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0764
M01RR000036 ( U.S. NIH Grant/Contract )
First Posted: September 8, 2000    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 2003

Keywords provided by National Center for Research Resources (NCRR):

Additional relevant MeSH terms:
Fractures, Bone
Hip Fractures
Muscular Atrophy
Wounds and Injuries
Pathological Conditions, Anatomical
Femoral Fractures
Hip Injuries
Leg Injuries
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms