Effects of Exercise on Markers of Inflammation in Skeletal Muscle in Elderly Hip Fracture Patients

This study has been completed.
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
First received: September 7, 2000
Last updated: June 23, 2005
Last verified: December 2003
Decreased skeletal muscle mass is a prevalent condition among the elderly, and an important cause of disability and functional decline. The declines in muscle mass associated with aging may be related to alterations in specific kinds of growth factors in the muscle. Elderly hip fracture patients often have significant decreases in muscle mass. The purpose of this study is to investigate whether an exercise program can induce changes in muscle growth factors that are associated with increases in muscle mass and strength in elderly hip fracture patients.

Condition Intervention
Hip Fractures
Muscular Atrophy
Behavioral: Exercise

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by National Center for Research Resources (NCRR):


Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Enrollment in HSC protocol #97-0695 "Rehabilitation Intensification Post Hip Fracture"
  • Community-dwelling
  • Hip fracture within 16 weeks of the screening assessment for protocol 97-0695
  • Persistent mobility and/or ADL impairments, but independent in ambulation
  • Modified Physical Performance Test (PPT) score between 12 and 28
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00006194

United States, Missouri
Washington University
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
National Center for Research Resources (NCRR)
  More Information

ClinicalTrials.gov Identifier: NCT00006194     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0764  M01RR000036 
Study First Received: September 7, 2000
Last Updated: June 23, 2005
Health Authority: United States: Federal Government

Keywords provided by National Center for Research Resources (NCRR):

Additional relevant MeSH terms:
Hip Fractures
Muscular Atrophy
Femoral Fractures
Fractures, Bone
Hip Injuries
Leg Injuries
Nervous System Diseases
Neurologic Manifestations
Neuromuscular Manifestations
Pathological Conditions, Anatomical
Signs and Symptoms
Wounds and Injuries

ClinicalTrials.gov processed this record on May 26, 2016