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Diagnostic Pilot Study of Dual Energy Absorptiometry in the Detection of Osteopenia or Osteoporosis in Patients With Thalassemia Major

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ClinicalTrials.gov Identifier: NCT00006138
Recruitment Status : Completed
First Posted : August 4, 2000
Last Update Posted : June 24, 2005
Children's Hospital of Philadelphia
Information provided by:
Office of Rare Diseases (ORD)

Brief Summary:


I. Determine the frequency and severity of osteopenia and osteoporosis in patients with thalassemia major who undergo dual energy x-ray absorptiometry, and correlate these findings with other relevant endocrinologic measurements.

Condition or disease
Osteoporosis Thalassemia Major Osteopenia

Detailed Description:


Patients undergo dual energy x-ray absorptiometry for bone density measurements, height (sitting and standing) and weight measurements, comprehensive endocrinologic examination, and assessment of the severity of iron overload at baseline, and then at years 1 and 2.

Study Type : Observational
Estimated Enrollment : 35 participants
Primary Purpose: Screening
Study Start Date : June 1998
Estimated Study Completion Date : August 2000

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Information from the National Library of Medicine

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Ages Eligible for Study:   6 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
  • Diagnosis of thalassemia major with iron overload
  • Not pregnant
  • Negative pregnancy test

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00006138

Sponsors and Collaborators
National Center for Research Resources (NCRR)
Children's Hospital of Philadelphia
Study Chair: Alan Richard Cohen Children's Hospital of Philadelphia

ClinicalTrials.gov Identifier: NCT00006138     History of Changes
Other Study ID Numbers: 199/15314
First Posted: August 4, 2000    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: October 2000

Keywords provided by Office of Rare Diseases (ORD):
disease-related problem/condition
genetic diseases and dysmorphic syndromes
hematologic disorders
rare disease
thalassemia major

Additional relevant MeSH terms:
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn