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Does Islet Transplantation Eliminate Hypoglycemia?

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2001 by National Center for Research Resources (NCRR).
Recruitment status was:  Not yet recruiting
Information provided by:
National Center for Research Resources (NCRR) Identifier:
First received: July 18, 2000
Last updated: June 23, 2005
Last verified: November 2001
Low blood sugar (hypoglycemia) is a recurrent problem for many people with diabetes. Successful transplantation of clusters (islets) of normal cells, that include those which produce the sugar-lowering hormone insulin, from the pancreas of a person who did not have diabetes into a person with diabetes should eliminate high blood sugar levels. We wish to determine if it will also eliminate low blood sugar. To do so we will give insulin to lower the blood sugar, measure the levels of the hormones that normally raise blood sugar levels (e.g., glucagon and epinephrine) and then stop the insulin and see if blood sugar levels return to normal. Because we anticipate that the transplanted islets will produce insulin, but not glucagon, this study may also tell us if regulated insulin production alone can prevent hypoglycemia in humans.

Condition Intervention
Diabetes Mellitus Procedure: Pancreatic Islet Transplantation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Masking: Single
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by National Center for Research Resources (NCRR):


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Clinically stable, insulin dependent islet transplant recipients and matched nondiabetic healthy controls
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00006068

Contact: Philip E. Cryer, M.D. 1-314-362-7635

Sponsors and Collaborators
National Center for Research Resources (NCRR)
  More Information Identifier: NCT00006068     History of Changes
Other Study ID Numbers: NCRR-M01RR00036-0746
M01RR000036 ( U.S. NIH Grant/Contract )
Study First Received: July 18, 2000
Last Updated: June 23, 2005

Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases processed this record on September 21, 2017