Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis
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|ClinicalTrials.gov Identifier: NCT00006060|
Recruitment Status : Unknown
Verified March 2009 by Office of Rare Diseases (ORD).
Recruitment status was: Recruiting
First Posted : July 6, 2000
Last Update Posted : March 12, 2009
OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced T1 lesion volume, and the magnetization transfer ratio histogram parameters, and correlate these measurements with clinical measures of disability in patients with multiple sclerosis.
II. Measure the quantity of whole brain N-acetylaspartate in patients with multiple sclerosis and compare these values to those from age matched controls.
III. Determine the correlation between specific neuropsychological tests which assess global cognitive functioning and the quantitative measurements taken in these patients in this study.
|Condition or disease||Intervention/treatment|
|Multiple Sclerosis||Drug: standard gadolinium contrast|
Patients undergo magnetic resonance imaging and spectroscopy with standard gadolinium contrast followed by neuropsychological testing every 6 months for 5 years. An equal number of age and sex matched healthy patients act as a control group and undergo magnetic resonance imaging and spectroscopy without standard gadolinium contrast every 6 months for 5 years.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Study Start Date :||April 1999|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00006060
|Contact: Robert I. Grossman, MD||212-263-3269|
|United States, New York|
|New York University Medical Center||Recruiting|
|New York, New York, United States, 10016|
|Contact: Lois J. Mannon, BSRT, (MR) (R) CCRC 212-263-3783 firstname.lastname@example.org|
|Principal Investigator: Robert I. Grossman, MD|
|Study Chair:||Robert I. Grossman, MD||New York University|