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The Effect of Estrogen and Progesterone Levels on Knee and Ankle Joint Laxity

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2001 by National Center for Research Resources (NCRR).
Recruitment status was:  Active, not recruiting
Information provided by:
National Center for Research Resources (NCRR) Identifier:
First received: June 23, 2000
Last updated: June 23, 2005
Last verified: November 2001
The proposed research is an observational study designed to compare estrogen and progesterone serum levels with knee and ankle joint laxity, and muscle reaction time as a measure of neuromuscular function. Three groups of women athletes with differing estrogen and progesterone profiles (normal menstrual cycles, amenorrheic, and exogenous estrogen supplementation) and one control group (male collegiate athletes) will be used to compare differences in joint laxity and neuromuscular function. Blood levels of estrogen and progesterone will be measured at four time points across the menstrual cycle. Joint laxity and muscle reaction time will also be measured at each of these points. The investigator hypothesizes that knee and ankle joint laxity and muscle reaction time will significantly increase with increasing estrogen and progesterone levels.


Study Type: Observational
Study Design: Observational Model: Natural History

Further study details as provided by National Center for Research Resources (NCRR):


Ages Eligible for Study:   15 Years to 23 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • pre-collegiate or collegiate athletes
  Contacts and Locations
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Please refer to this study by its identifier: NCT00005923

United States, Vermont
University of Vermont
Burlington, Vermont, United States, 05405
Sponsors and Collaborators
National Center for Research Resources (NCRR)
  More Information Identifier: NCT00005923     History of Changes
Other Study ID Numbers: NCRR-M01RR00109-0749
M01RR000109 ( US NIH Grant/Contract Award Number )
Study First Received: June 23, 2000
Last Updated: June 23, 2005

Keywords provided by National Center for Research Resources (NCRR):
Joint Instability processed this record on May 25, 2017