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Trial record 28 of 557 for:    Genetic AND family history

Genetics of Recurrent Early-Onset Depression (GenRED)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00005914
Recruitment Status : Completed
First Posted : June 16, 2000
Last Update Posted : April 19, 2019
Sponsor:
Collaborator:
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Douglas F. Levinson, Stanford University

Brief Summary:

This nationwide study will create a DNA collection to permit qualified scientists to search for depression-related genes.

More than 750 families with at least two siblings who have experienced major depression are needed for the study. Participants will be interviewed about psychiatric and family history, and will be asked to provide a small blood specimen. The identification of predisposing genes can lead to greater understanding of the brain mechanisms involved in severe depression which can in turn lead to the discovery of new treatments.

A Certificate of Confidentiality from the federal government ensures that all information will be strictly confidential. Blood specimens are identified only by code number (not by name).

Reimbursement is provided.


Condition or disease
Depression

Detailed Description:

Studies of patterns of major depression in families suggest that 50 to 70% of the predisposition to major depression is caused by genes. People with recurrent depression and earlier ages of onset have more relatives with depression. There are probably at least several interacting genes, rather than a single gene as in some disorders. The identification of predisposing genes is likely to lead to greater understanding of the brain mechanisms involved in severe depression. This could lead to the discovery of new treatments.

This study will create a DNA collection to permit qualified scientists to search for depression-related genes. More than 750 families with at least two siblings who have experienced major depression are needed for the study.

Participants in this study will be interviewed about psychiatric and family history, and will be asked for a small blood specimen. Interviews can be conducted in person or by telephone. For telephone interviews, blood sample collection will be arranged at a location and time convenient for the participant. Participants will also be asked for help in inviting other family members to participate. No family member will be contacted without the permission and assistance of another participating family member.

For information on a related study, please follow this link:

http://clinicaltrials.gov/show/NCT00260182


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Study Type : Observational
Actual Enrollment : 2533 participants
Observational Model: Family-Based
Time Perspective: Retrospective
Official Title: Genetics of Recurrent Early-Onset Depression
Study Start Date : October 1999
Actual Primary Completion Date : October 2005
Actual Study Completion Date : October 2005

Resource links provided by the National Library of Medicine


Group/Cohort
Probands and family members
Individuals with major depressive disorder who meet study criteria, and members of their families. No intervention. This is a genetic study only.



Primary Outcome Measures :
  1. Major depressive disorder [ Time Frame: One patient interview session (typically 2 hours), and blood draw (10-20 minutes) ]
    Participants will attend an interview regarding personal and family history of psychiatric disorders, and give a blood specimen. Genotypes from blood samples will be studied for genetic linkage (within families) with the presence of major depressive disorder.


Biospecimen Retention:   Samples With DNA
Blood specimens were submitted to the NIMH repository at the Rutgers University Cell and DNA Repository.


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Probands will have major depressive disorder meeting the eligibility criteria described below.
Criteria

Inclusion Criteria:

  • Families that have at least TWO ADULT SIBLINGS (brother/brother; sister/sister; brother/sister) who have experienced major depression.
  • Depression must be RECURRENT (more than one episode).
  • Depression must have started at age 30 or less in one sibling, and at age 40 or less in the other sibling.

Exclusion Criteria:

  • Participants cannot have Bipolar I (manic-depressive) disorder or schizophrenia.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005914


Locations
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United States, Illinois
Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, United States, 60612
United States, Iowa
Univ of Iowa Hosp and Clinic
Iowa City, Iowa, United States, 52242
United States, Maryland
Johns Hopkins University
Baltimore, Maryland, United States, 21287-7381
United States, New York
New York State Psychiatric Institute / Columbia Univ
New York, New York, United States, 10032
United States, Pennsylvania
Univ of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104-2648
Univ of Pittsburgh / Western Psychiatric Inst and Clinic
Pittsburgh, Pennsylvania, United States, 15213
Sponsors and Collaborators
Stanford University
National Institute of Mental Health (NIMH)
Investigators
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Principal Investigator: Myrna Weissman Columbia University
Principal Investigator: J R DePaulo Johns Hopkins University
Principal Investigator: William Scheftner Rush University Hospital
Principal Investigator: Raymond Crowe University of Iowa
Principal Investigator: Douglas Levinson University of Pennsylvania
Principal Investigator: George Zubenko University of Pittsburgh

Additional Information:
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Responsible Party: Douglas F. Levinson, Principle Investigator, Stanford University
ClinicalTrials.gov Identifier: NCT00005914     History of Changes
Other Study ID Numbers: R01MH061686-01 ( U.S. NIH Grant/Contract )
R01MH061686-01 ( U.S. NIH Grant/Contract )
R01MH060912 ( U.S. NIH Grant/Contract )
R01MH059552 ( U.S. NIH Grant/Contract )
R01MH059541 ( U.S. NIH Grant/Contract )
R01MH059542 ( U.S. NIH Grant/Contract )
R01MH061686 ( U.S. NIH Grant/Contract )
R01MH060866 ( U.S. NIH Grant/Contract )
DNBBS 7G-GRR
First Posted: June 16, 2000    Key Record Dates
Last Update Posted: April 19, 2019
Last Verified: April 2019

Keywords provided by Douglas F. Levinson, Stanford University:
Depression
Depressive Disorder
Family
Genes
Genetic Techniques
Genetics
Linkage (Genetics)
Nuclear Family
Recurrence
Severity of Illness Index

Additional relevant MeSH terms:
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Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders