Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors
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|ClinicalTrials.gov Identifier: NCT00005790|
Recruitment Status : Withdrawn (Unable to accrue subjects.)
First Posted : June 9, 2004
Last Update Posted : June 11, 2012
RATIONALE: Perfusion magnetic resonance imaging may be an effective method of measuring the growth of blood vessels in brain tumors. These measurements may help doctors better diagnose and treat brain tumors.
PURPOSE: Pilot study to determine the effectiveness of perfusion magnetic resonance imaging in measuring the growth of blood vessels in newly diagnosed brain tumors.
|Condition or disease||Intervention/treatment|
|Brain and Central Nervous System Tumors||Other: laboratory biomarker analysis Procedure: biopsy Procedure: magnetic resonance imaging Radiation: gadopentetate dimeglumine|
OBJECTIVES: I. Correlate the findings of perfusion magnetic resonance imaging with known tissue and serum markers of angiogenesis in patients with newly diagnosed surgically resectable brain tumors.
OUTLINE: Patients undergo perfusion magnetic resonance imaging (MRI) scanning with contrast in conjunction with preoperative conventional MRI scanning with contrast. Patients receive gadopentetate dimeglumine IV over 5 seconds prior to perfusion MRI. Gadopentetate dimeglumine is administered at a slower rate prior to conventional MRI. Patients undergo blood draw to determine urokinase type plasminogen activator levels. After completion of perfusion and conventional MRI scanning, brain tumor tissue samples are obtained during surgical resection to determine tumor grade and type and urokinase type plasminogen activator and basic fibroblast growth factor levels. If CSF removal is required during surgery, then CSF samples are collected to determine urokinase type plasminogen activator and basic fibroblast growth factor levels.
PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Official Title:||Perfusion Magnetic Resonance Imaging of Brain Tumors: Correlation With Indicators of Angiogenesis|
|Study Start Date :||April 1996|
|Estimated Primary Completion Date :||May 1999|
|Estimated Study Completion Date :||May 1999|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005790
|Study Chair:||Hunt H. Batjer, MD||Robert H. Lurie Cancer Center|