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Dynamic Aspects of Amino Acid Metabolism

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ClinicalTrials.gov Identifier: NCT00005767
Recruitment Status : Unknown
Verified December 2003 by National Center for Research Resources (NCRR).
Recruitment status was:  Recruiting
First Posted : June 2, 2000
Last Update Posted : June 24, 2005
Information provided by:
National Center for Research Resources (NCRR)

Brief Summary:
This protocol seeks to define aspects of intestinal and hepatic uptake and metabolism of several amino acids. The major hypothesis to be tested is that the splanchic bed (intestine and liver) conserves essential amino acids and metabolites while synthesizing and metabolizing nonessential amino acids. The aims of the study include defining the relative roles of enteral and hepatic extraction/metabolism in the disposition of glutamate, alanine, methionine and other amino acids. Emphasis will also be placed on studies of the transamination of alpha-ketoisocaproic acid (KIC) to leucine since this reaction is of potential importance in the design of nutritional regimens for patients with renal disease.

Condition or disease
Kidney Diseases

Study Type : Observational
Observational Model: Natural History
Time Perspective: Cross-Sectional

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Diseases
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • normal weight-for-height weight 50-80 kg
  • normal physical activity
  • no significant medical history
  • healthy by medical exam and lab blood testing

Exclusion Criteria:

  • subjects who exercise vigorously
  • subjects who smoke

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005767

Contact: Dwight Matthews, Ph.D. 1-802-646-8114

United States, Vermont
University of Vermont Recruiting
Burlington, Vermont, United States, 05401
Contact: Dwight Matthews, Ph.D.    802-646-8114      
Sponsors and Collaborators
National Center for Research Resources (NCRR)

ClinicalTrials.gov Identifier: NCT00005767     History of Changes
Other Study ID Numbers: NCRR-M01RR00109-0740
M01RR000109 ( U.S. NIH Grant/Contract )
First Posted: June 2, 2000    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: December 2003

Keywords provided by National Center for Research Resources (NCRR):
Amino Acid Metabolism

Additional relevant MeSH terms:
Kidney Diseases
Urologic Diseases