Epidemiology of Sleep-Disordered Breathing in Adults
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|ClinicalTrials.gov Identifier: NCT00005557|
Recruitment Status : Enrolling by invitation
First Posted : May 26, 2000
Last Update Posted : November 1, 2016
|Condition or disease|
|Sleep Disorders Cerebrovascular Disorders Cardiovascular Disease Neurologic Disorders Mood Disorders|
Recent research has shown that sleep disordered breathing (SDB) is much more common than previously thought. While it is known that in clinic samples, SDB is associated with hypertension, cardiovascular disease and mortality, little is known about the natural history of this disorder, particularly in the general population, nor about the causal role of known risk factors. The knowledge obtained from the results of this study will help advance the field of sleep disorders medicine. Information about longitudinal effects and causal relationships may be applied to clinical situations, thus reducing the morbidity and mortality associated with this disorder.
In this longitudinal study, follow-up polysomnography and other protocols are conducted on an established cohort of men and women (age 30-60 years at the time of initial recruitment in 1989), currently enrolled in the Wisconsin Sleep Cohort Study. The study aims to : 1) describe the natural history of SDB across middle and older age; 2) investigate associations of SDB with early and intermediate markers of cardiovascular dysfunction, damage, and cardiovascular disease; 3) investigate the longitudinal association of SDB in accelerated cognitive decline; 4) investigate the association of SDB and adverse sleep characteristics with age-related risk factors and outcomes.
|Study Type :||Observational|
|Actual Enrollment :||1545 participants|
|Official Title:||Epidemiology of Sleep-Disordered Breathing in Adults|
|Study Start Date :||April 1999|
|Estimated Primary Completion Date :||April 2022|
|Estimated Study Completion Date :||April 2023|
- sleep disorders and problems, cardiovascular and cognitive outcomes [ Time Frame: measured at each study visit ]Overnight polysomnography is used to assess sleep pathology. Questionnaires are used to assess sleep habits. A variety of clinical and laboratory assessments measure cardiovascular and cognitive outcomes.
- cardiovascular outcomes [ Time Frame: measured at each study visit ]A variety of clinical and laboratory assessments measure cardiovascular outcomes.
- cognitive outcomes [ Time Frame: measured at each study visit ]A variety of clinical and laboratory assessments measure cognitive outcomes.
- gait and balance [ Time Frame: measured at each study visit ]A series of walking tests are conducted.
- mental health outcomes [ Time Frame: evaluated at each study visit ]Questionnaires assess mood, depression, and anxiety.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005557
|United States, Wisconsin|
|University of Wisconsin Hospital and Clinics|
|Madison, Wisconsin, United States, 53705|
|Principal Investigator:||Paul E Peppard, PhD||University of Wisconsin, Madison|