Arterial Endothelial Function--An Epidemiologic Study
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|ClinicalTrials.gov Identifier: NCT00005545|
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : December 12, 2013
|Condition or disease|
|Cardiovascular Diseases Heart Diseases Coronary Arteriosclerosis Carotid Artery Diseases|
Many young adult subjects have some degree of atherosclerotic coronary and carotid artery disease and experience no symptoms. As time passes, many die suddenly and unexpectedly and only limited therapeutic process begins in youth, a measure of the early manifestations of atherosclerosis may have the potential of identifying subjects at risk for premature coronary and carotid occlusive vascular disease when therapeutic options can be administered. Impaired brachial artery flow mediated dilatory (FMD) capacities have been shown to exist in children and young adults with hypercholesterolemia, hyperhomocysteinemia, diabetes and in those who smoke. Impaired brachial artery FMD has been shown to related to impaired endothelial function, which is an early manifestation of the atherosclerotic process. If impaired brachial artery FMD is a predictor of the process, then it may be used to non-invasively assess atherosclerosis early in its development and to evaluate the effect of therapeutic interventions.
In this longitudinal study using previously studied members of the Muscatine study, measurements are made of contemporaneous risk factors, and brachial artery FMD, along with coronary artery calcification (CAC) and carotid artery intimal-medial thickness (IMT) (the latter two established measures of early atherosclerosis) and again three years later. The effort is designed to examine the following hypotheses: 1) Established risk factor levels measured in childhood, adulthood and across the years form childhood through adulthood are predictive of brachial artery flow mediated dilatory (FMD) capacities; 2) Putative risk factor levels measured in adulthood are related to the degree of brachial artery FMD, CAC and carotid artery IMT; 3) Brachial artery FMD, CAC and carotid artery IMTare related in adults; and 4) Brachial artery FMD is predictive of increased carotid artery IMT.
|Study Type :||Observational|
|Actual Enrollment :||600 participants|
|Official Title:||Arterial Endothelial Function--An Epidemiologic Study|
|Study Start Date :||December 1998|
|Actual Primary Completion Date :||May 2009|
|Actual Study Completion Date :||May 2009|
- Flow-mediated dilatation [ Time Frame: 1999 to 2008 ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005545
|Principal Investigator:||Ronald Lauer||University of Iowa|