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Diet, Insulin Resistance, and Cardiovascular Risk

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of South Carolina Identifier:
First received: May 25, 2000
Last updated: May 10, 2016
Last verified: May 2016
To elucidate dietary factors that elevate risk for cardiovascular disease (CVD) in conjunction with insulin resistance.

Cardiovascular Diseases Heart Diseases Insulin Resistance Hyperinsulinism Diabetes Mellitus, Non-insulin Dependent Diabetes Mellitus

Study Type: Observational

Further study details as provided by University of South Carolina:

Study Start Date: May 1994
Estimated Study Completion Date: April 2000
Detailed Description:


Clinical studies indicate that high carbohydrate intake may exacerbate the dyslipidemia often seen with insulin resistance. Consequently, there is much debate as to the optimal dietary pattern for individuals with NIDDM to minimize risk for microvascular disease. Data on this topic from free-living populations are scarce. In addition, associations of dietary antioxidants with CVD risk have not been evaluated in large community samples of persons with diabetes.


Potential dietary determinants of hyperinsulinemia or of insulin resistance were evaluated, including high intake of dietary fats and of simple sugars and low alcohol consumption. As a major focus, dietary factors that may contribute to elevated CVD risk among persons with existing insulin resistance, including impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) were examined. Five datasets from epidemiologic studies were available to evaluate specific hypotheses for men and women of Black, Hispanic and non-Hispanic white ethnicity. The unique contributions of each dataset were as follows. The San Luis Valley Diabetes Study and the San Antonio Heart Study enabled prospective analyses for large numbers of subjects with IGT or NIDDM; the Mexico City Study provided a sample with contrasting dietary patterns in a non-white population; the Kaiser Permanente Women Twins Study allowed for the removal of genetic influences by evaluating associations within monozygotic twin pairs; and the Insulin Resistance Atherosclerosis Study (IRAS) provided direct measurement of insulin sensitivity and subclinical atherosclerosis across the spectrum of glucose tolerance in three ethnic groups.

An understanding of the accuracy of the dietary assessment instruments used in the three ethnic groups was critical to the interpretation of the findings related to diet and CVD risk variables. Therefore, a second component of research was also conducted, that being an evaluation of the comparative validity of the food frequency interview used in the multi- cultural IRAS population using a series of 24-hour dietary recalls as the standard.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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Please refer to this study by its identifier: NCT00005530

Sponsors and Collaborators
University of South Carolina
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Elizabeth Mayer-Davis University of South Carolina
  More Information

Publications: Identifier: NCT00005530     History of Changes
Other Study ID Numbers: 5063
R29HL053798 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: May 10, 2016

Additional relevant MeSH terms:
Diabetes Mellitus
Cardiovascular Diseases
Heart Diseases
Insulin Resistance
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases processed this record on September 21, 2017