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Genetic Epidemiology--Development of Cardiovascular Risk

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Virginia Commonwealth University Identifier:
First received: May 25, 2000
Last updated: February 29, 2016
Last verified: February 2016
To determine how genetic and environmental factors influence the co-occurrence of obesity and hypertension during development and to identify cardiovascular risk factors in adolescence that will predict cardiovascular disease in adults.

Cardiovascular Diseases Hypertension Obesity Heart Diseases

Study Type: Observational

Further study details as provided by Virginia Commonwealth University:

Study Start Date: August 1998
Estimated Study Completion Date: July 2002
Detailed Description:


Obesity and hypertension are two of the major risk factors for cardiovascular disease (CVD) and those with obesity have a greater risk of hypertension. In children and adolescents, high body mass index correlates with elevated blood pressure. Genetic factors make a significant contribution to the variation of obesity and hypertension.


Anthropometric, cardiovascular, physiologic and physical fitness data were used to investigate a series of critical issues about the etiology, heterogeneity, comorbidity and developmental trajectories of CVD risk factors, including obesity, hypertension and cardiovascular health. Using the two datasets, the main questions of the study were addressed. How do genes and environment act and interact to create covariation between obesity and hypertension, and were the genetic and environmental factors the same at all ages (from childhood to late adolescence and adulthood) in both sexes? Areas of research included the following: causes of individual differences in anthropometric and cardiovascular characteristics, their covariation and developmental change or continuity in adolescence, parent-offspring transmission, prediction of cardiovascular risk, and sex, race and population differences in genetic and environmental contributions on cardiovascular risk factors.


Ages Eligible for Study:   10 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria
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Please refer to this study by its identifier: NCT00005512

Sponsors and Collaborators
Virginia Commonwealth University
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Hermine Maes Virginia Commonwealth University
  More Information

Publications: Identifier: NCT00005512     History of Changes
Other Study ID Numbers: 5030
R01HL060688 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: February 29, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases processed this record on August 18, 2017