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Salt Sensitivity, Cardiovascular and Metabolic Disease

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Indiana University Identifier:
First received: May 25, 2000
Last updated: December 28, 2015
Last verified: December 2015
To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.

Cardiovascular Diseases Heart Diseases Hypertension Angina Pectoris Cerebrovascular Accident Myocardial Infarction Diabetes Mellitus Heart Failure, Congestive Heart Failure

Study Type: Observational

Further study details as provided by Indiana University:

Study Start Date: January 1998
Estimated Study Completion Date: December 2001
Detailed Description:


Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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Please refer to this study by its identifier: NCT00005489

Sponsors and Collaborators
Indiana University
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Myron Weinberger Indiana University-Purdue University
  More Information

Publications: Identifier: NCT00005489     History of Changes
Other Study ID Numbers: 5005
R01HL057826 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: December 28, 2015

Additional relevant MeSH terms:
Diabetes Mellitus
Heart Failure
Cardiovascular Diseases
Heart Diseases
Myocardial Infarction
Angina Pectoris
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Pathologic Processes
Myocardial Ischemia
Vascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Chest Pain
Neurologic Manifestations
Signs and Symptoms processed this record on July 25, 2017