Salt Sensitivity, Cardiovascular and Metabolic Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005489
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : December 30, 2015
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Indiana University

Brief Summary:
To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.

Condition or disease
Cardiovascular Diseases Heart Diseases Hypertension Angina Pectoris Cerebrovascular Accident Myocardial Infarction Diabetes Mellitus Heart Failure, Congestive Heart Failure

Detailed Description:


Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.

Study Type : Observational
Study Start Date : January 1998
Study Completion Date : December 2001

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00005489

Sponsors and Collaborators
Indiana University
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Myron Weinberger Indiana University-Purdue University

Publications: Identifier: NCT00005489     History of Changes
Other Study ID Numbers: 5005
R01HL057826 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: December 30, 2015
Last Verified: December 2015

Additional relevant MeSH terms:
Diabetes Mellitus
Heart Failure
Cardiovascular Diseases
Heart Diseases
Myocardial Infarction
Angina Pectoris
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Pathologic Processes
Myocardial Ischemia
Vascular Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Chest Pain
Neurologic Manifestations
Signs and Symptoms