Multi-Ethnic Study of Atherosclerosis (MESA)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2012 by National Heart, Lung, and Blood Institute (NHLBI).
Recruitment status was  Active, not recruiting
Information provided by (Responsible Party):
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: May 25, 2000
Last updated: June 2, 2015
Last verified: April 2012
To conduct a prospective observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced signs and symptoms) that predict progression to clinically overt cardiovascular disease in a diverse and representative population-based sample of men and women aged 35-84. Specifically the study shall: determine characteristics related to progression of subclinical to clinical cardiovascular disease; identify factors related to newer measures of subclinical disease and examine relationship of new to established measures; and develop population-based methods, suitable for application in future screening and intervention studies, for identifying asymptomatic persons at highest risk of clinical events.

Cardiovascular Diseases
Heart Diseases
Coronary Artery Disease
Coronary Disease
Myocardial Infarction
Heart Failure
Diabetes Mellitus, Type 2
Diabetes Mellitus

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Multi-Ethnic Study of Atherosclerosis (MESA)

Resource links provided by NLM:

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Estimated Enrollment: 6000
Study Start Date: January 1999
Estimated Study Completion Date: August 2015
Estimated Primary Completion Date: August 2015 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   45 Years to 84 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Participants were recruited from the MESA Study Field Centers.
No eligibility criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00005487

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: David Bluemke Johns Hopkins University
Principal Investigator: Gregory Burke Wake Forest School of Medicine
Principal Investigator: Aaron Folsom University of Minnesota - Clinical and Translational Science Institute
Principal Investigator: Richard Kronmal University of Washington
Principal Investigator: Kiang Liu Northwestern University
Principal Investigator: Daniel O'Leary New England Medical Center Hospitals
Principal Investigator: Steven Shea Columbia University
Principal Investigator: Moyses Szklo Johns Hopkins University
Principal Investigator: Russell Tracy University of Vermont
Principal Investigator: Matthew Budoff Los Angeles Biomedical Research Institute
Principal Investigator: Karol Watson University of California, Los Angeles
  More Information

Additional Information:
Auchincloss AH, Diez Roux AV, Brown DG, Erdmann CA, Bertoni AG. Associations between insulin resistance and resources for physical activity and healthy foods: the Multi-Ethnic Study of Atherosclerosis. Epidemiology. (In press)
Han C, Kronmal R. Two-part models for analysis of Agatston scores with possible proportionality constraints. Communications in Statistics-Theory and Methods. 2006;35(1):99-111.
Ix JH, Katz R, Kestenbaum B, Fried L, Kramer H, Stehman-Breen C, Shlipak M. Association of Mild to Moderate Decrements in Kidney Function and Coronary Calcification in the Multi-Ethnic Study of Atherosclerosis (MESA). Journal of the American Society of Nephrology. (In press)

Additional publications automatically indexed to this study by Identifier (NCT Number):
Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FA, Kovanen L, Bartz TM, Perälä MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkilä V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kähönen M, Havulinna AS, Siscovick DS, Räikkönen K, Jørgensen T, Rotter JI, Deloukas P, Viikari JS, Mozaffarian D, Linneberg A, Seppälä I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimäki T, Ordovás JM. Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015 Jan;101(1):135-43. doi: 10.3945/ajcn.114.095026. Epub 2014 Nov 26.
Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkilä V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC, Dhurandhar EJ, Feitosa MF, Johansson I, Khaw KT, Lohman KK, Manichaikul A, McKeown NM, Mozaffarian D, Singleton A, Stirrups K, Viikari J, Ye Z, Bandinelli S, Barroso I, Deloukas P, Forouhi NG, Hofman A, Liu Y, Lyytikäinen LP, North KE, Dimitriou M, Hallmans G, Kähönen M, Langenberg C, Ordovas JM, Uitterlinden AG, Hu FB, Kalafati IP, Raitakari O, Franco OH, Johnson A, Emilsson V, Schrack JA, Semba RD, Siscovick DS, Arnett DK, Borecki IB, Franks PW, Kritchevsky SB, Lehtimäki T, Loos RJ, Orho-Melander M, Rotter JI, Wareham NJ, Witteman JC, Ferrucci L, Dedoussis G, Cupples LA, Nettleton JA. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr. 2013 Jun;97(6):1395-402. doi: 10.3945/ajcn.112.052183. Epub 2013 May 1.

Responsible Party: National Heart, Lung, and Blood Institute (NHLBI) Identifier: NCT00005487     History of Changes
Other Study ID Numbers: 5003
Study First Received: May 25, 2000
Last Updated: June 2, 2015
Health Authority: United States: Federal Government

Keywords provided by National Heart, Lung, and Blood Institute (NHLBI):
Coronary Arteriosclerosis
Cerebrovascular Accident
Heart Failure, Congestive
Diabetes Mellitus, Non-Insulin Dependent

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Diabetes Mellitus
Diabetes Mellitus, Type 2
Heart Failure
Myocardial Infarction
Myocardial Ischemia
Arterial Occlusive Diseases
Endocrine System Diseases
Glucose Metabolism Disorders
Heart Diseases
Metabolic Diseases
Vascular Diseases processed this record on November 30, 2015