Indices of Severity and Prognosis for Sickle Cell Disease
To develop a clinical severity index that could prospectively identify sickle cell disease patients who were at high risk for a turbulent clinical course and a poor prognosis.
Anemia, Sickle Cell
|Study Design:||Observational Model: Natural History|
|Study Start Date:||January 1990|
|Estimated Study Completion Date:||December 1992|
Using the database, univariate analysis showed that factors associated with the occurrence of cerebrovascular accident (51 patients) included hematocrit, rate of change of pocked red cell count, and polymer fraction at 40 percent oxygen saturation (PF40). Only low hematocrit was predictive of death in the pediatric cohort. There were 45 disease-related deaths.
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