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Social Support and Myocardial Ischemia

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of Florida Identifier:
First received: May 25, 2000
Last updated: January 7, 2016
Last verified: January 2016
To examine the role of social support in attenuating ischemic responses to psychological stress, both in the laboratory and during daily life.

Cardiovascular Diseases
Heart Diseases
Myocardial Ischemia
Coronary Disease

Study Type: Observational

Further study details as provided by University of Florida:

Study Start Date: August 1996
Estimated Study Completion Date: June 2001
Detailed Description:


A large quantity of epidemiological data has accumulated attesting to a link between social support and the progression of cardiovascular disease in cardiac patients. One way that social support might exerts its health effects is by attenuating physiological responses to psychological stress, since these responses have been related to cardiovascular disease. Much myocardial ischemia occurring during daily life appears to be related to periods of psychological stress, and laboratory mental stress tasks have been found to induce ischemia. Thus, the incidence, severity, and duration of myocardial ischemia might be modified by changes in the social environment.


There are two components to the study. In the first component, the investigators are testing the hypothesis that the presence of a supportive spouse attenuates ischemic responses to psychological stress in the laboratory. Using a counterbalanced crossover, repeated measures design, patients are asked to complete a public speaking task in the laboratory in two conditions: with a spouse present; and alone. Hemodynamic, radionuclide angiographic, and catecholamine responses to the task are assessed in both conditions.

In the second component, the investigators are examining whether married patients show reduced duration of ischemia compared to unmarried patients. In addition, they plan to examine whether presence of a supportive other (spouse, or friend in the case of unmarried patients) reduces the incidence and duration of ischemia in patients during daily life activities. Patients are asked to keep a detailed diary for a two week period to ascertain patterns of daily activities. Using these diaries and in consultation with patients, the investigators are selecting a two day period during which patients have a busy and varied schedule. Patients are then asked to follow the same pattern of activities for a 48 hour period on two consecutive weeks when heart rate, and the incidence and duration of ischemia are measured. During one week their spouse, in the case of married patients, or friend, in the case of unmarried patients, is present; during the other week patients are to repeat the activities alone.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
  Contacts and Locations
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No Contacts or Locations Provided
  More Information

Publications: Identifier: NCT00005449     History of Changes
Other Study ID Numbers: 4378
R29HL056825 ( US NIH Grant/Contract Award Number )
Study First Received: May 25, 2000
Last Updated: January 7, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Myocardial Ischemia
Coronary Artery Disease
Coronary Disease
Pathologic Processes
Vascular Diseases
Arterial Occlusive Diseases processed this record on March 24, 2017