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Stroke Risk in the NAS-NRC Twin Registry

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00005413
First Posted: May 26, 2000
Last Update Posted: May 13, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
  Purpose
To investigate stroke risk using the National Academy of Sciences Twin Registry.

Condition
Cardiovascular Diseases Cerebrovascular Accident Myocardial Infarction Coronary Disease

Study Type: Observational

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: September 1991
Study Completion Date: September 1993
Detailed Description:

BACKGROUND:

The epidemiology and common risk factors for cerebrovascular disease have been well documented by cross-sectional and longitudinal population surveys. These studies have generally involved unrelated individuals with little information on family history. Despite a significant role in cardiovascular risk, few studies have investigated familial contributions to stroke risk, and its importance was unknown. Recognition of the importance of hereditary influences on vascular disease of the heart has contributed, in large part, to the current emphasis on the molecular biology of vascular disease and a more balanced view that recognized both genetic and environmental influences on coronary artery disease. Twin studies represented a simple and uniquely powerful tool for analyzing genetic and environmental contributions to complex human phenotypes. Studies of cardiovascular risk have shown the importance of heritable factors, and it was hypothesized that similar genetic factors played a role in development of stroke.

With improved understanding of stroke risk factors (both genetic and environmental), early prevention measures can begin in high risk groups as early as childhood, an approach already applied to cardiovascular disease. Demonstration of a significant heritable risk for stroke should also prompt and help direct, further investigation into the molecular mechanisms of the genetic influences on stroke and may identify new approaches for stroke prevention and treatment, as it has for cardiovascular disease.

DESIGN NARRATIVE:

The twins have been surveyed periodically over the past two decades, most recently in 1985. Information obtained included questions on vascular risk factors, myocardial disease, and stroke. An analysis was made on an estimation of heritable risk. A comparison was made between monozygotic (MZ) and dizygotic (DZ) twins. If genes influenced the prevalence of stroke, there should have been more MZ twin pairs with stroke. Measures of concordance and heritability were used to estimate the size of the genetic contribution. Secondary analyses focussed on compound risk factors (e.g. hypertension and diabetes), less well documented risk factors (e.g. diet and personality), and the heritability of individual stroke risk factors.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria
No eligibility criteria
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005413


Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
OverallOfficial: Lawrence Brass Yale University
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00005413     History of Changes
Other Study ID Numbers: 4331
R03HL047451 ( U.S. NIH Grant/Contract )
First Submitted: May 25, 2000
First Posted: May 26, 2000
Last Update Posted: May 13, 2016
Last Verified: March 2005

Additional relevant MeSH terms:
Infarction
Cardiovascular Diseases
Myocardial Infarction
Coronary Disease
Coronary Artery Disease
Stroke
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases