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University of North Carolina Alumni Heart Study

This study is ongoing, but not recruiting participants.
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Duke University Identifier:
First received: May 25, 2000
Last updated: June 29, 2017
Last verified: June 2017
To continue surveillance of the participants in the University of North Carolina Alumni Heart Study, which tests the hypothesis that hostility and related psychosocial factors are involved in the pathogenesis of coronary heart disease.

Condition Intervention
Cardiovascular Diseases Heart Diseases Coronary Disease Depression Other: There is no intervention

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: University of North Carolina Alumni Heart Study

Resource links provided by NLM:

Further study details as provided by Duke University:

Primary Outcome Measures:
  • Coronary Heart Disease [ Time Frame: approximately 30 years ]
    This is a descriptive cohort study

Enrollment: 6340
Study Start Date: May 1996
Estimated Primary Completion Date: May 2026 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1; no experimental groups in this study
Observational cohort study
Other: There is no intervention
No applicable

Detailed Description:


Prevention of coronary heart disease (CHD) will be enhanced by controlling hypertension, reducing blood cholesterol, maintaining normal weight, increasing physical activity, reducing smoking, and having a healthy diet. Understanding how to achieve these important public health aims requires an understanding of the behavioral factors involved in prevention. Behavioral risk factors remain the single most preventable cause of human illness and suffering. The University of North Carolina Alumni Heart Study is ideally suited to explore the associations between and among these important behavioral risk factors, and to understand how personality, in particular individual differences in hostility and depression act to determine individuals' risk factor behaviors, and to answer important questions about the role of hostility and psychosocial factors in CHD risk during the middle years.

The University of North Carolina Alumni Heart Study (UNCAHS) is a prospective study of the role of psychosocial factors, in particular hostility, in the development of coronary heart disease. The target population is composed of persons who completed the Minnesota Multiphasic Personality Inventory while attending the University of North Carolina in the mid-1960s.


Surveillance of the members of the UNC Alumni Heart Study continues for an additional five-year period . Studies continue on how hostility and other psychosocial factors are related to each other and how they contribute to coronary heart disease risk. Data are analyzed in order to test hypotheses about the role of psychosocial factors in weight parameters, dietary practices and the contribution of spouse hostility to coronary risk.

To better understand the dynamic interrelationships of psychosocial and behavioral risk factors of the adult life span, the trajectories of hostility, depression, smoking, body mass, exercise patterns, and alcohol consumption will be mapped using multiple assessments from age 19 to age 60. It is predicted that a significant proportion of the change in risk behavior will be due to trajectories of hostility and depression, operating singly and in combination over time. Tests will be made of the prospective associations of hostility, depression, and other psychosocial variables (e.g., social support and job strain) with coronary events and mortality observed while the cohort is middle-aged. The scope of the psychosocial variables will be broadened to examine individual differences in personality over the life course and dietary practices at midlife in addition to the indicators noted above. The effect of gender on the natural history of coronary disease and coronary risk profiles in women will be examined by monitoring changes in menopausal status, and patterns of hormone replacement therapy use among women during midlife and the associations of these factors with the other risk indicators.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
participants in the University of North Carolina Alumni Heart Study
No eligibility criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00005398

United States, North Carolina
Duke University, Behavioral Medicine Research Center
Durham, North Carolina, United States, 27705
Sponsors and Collaborators
Duke University
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Mental Health (NIMH)
Principal Investigator: Ilene C. Siegler, PhD, MPH Duke University
  More Information


Responsible Party: Duke University Identifier: NCT00005398     History of Changes
Other Study ID Numbers: Pro00013233
R01HL055356 ( U.S. NIH Grant/Contract )
P01HL036587 ( U.S. NIH Grant/Contract )
R01MH066079 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: June 29, 2017

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases processed this record on September 21, 2017