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Central Obesity and Disease Risk in Japanese Americans

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of Washington Identifier:
First received: May 25, 2000
Last updated: February 8, 2016
Last verified: August 2004
To conduct a longitudinal study of central obesity and related risk factors found to be associated with hypertension and atherosclerotic cardiovascular disease (ASCVD) in a previously-examined cross-sectional cohort of second-generation Japanese Americans and in a newly-recruited cohort of third generation Japanese Americans.

Cardiovascular Diseases Heart Diseases Atherosclerosis Hypertension Obesity Diabetes Mellitus, Non-insulin Dependent Hyperinsulinism Insulin Resistance Coronary Arteriosclerosis Diabetes Mellitus Metabolic Syndrome X

Study Type: Observational

Resource links provided by NLM:

Further study details as provided by University of Washington:

Study Start Date: February 1993
Estimated Study Completion Date: January 1998
Detailed Description:


The study was conducted in response to a program announcment issued in 1991 on obesity and tests the hypothesis that atherosclerotic cardiovascular disease (ASCVD), hypertension, and/or non-insulin dependent diabetes mellitus (NIDDM) develop in Japanese Americans when there is a truncal pattern of weight gain (central adiposity), which is in turn accompanied by insulin resistance, hyperinsulinemia, and lipid abnormalities. This cluster of abnormalities has been called 'Syndrome X'. It is postulated that 'Syndrome X' develops in Japanese Americans in response to environmental (behavioral) factors, many of which reflect 'westernization' in this ethnic group. The research plan focuses upon the relationship between central obesity and metabolic changes and disease outcomes associated with 'Syndrome X' along with the behavioral variables that potential risk factors for the development of this cluster of abnormalities.


The cohort was re-examined for diabetes, hypertension, coronary heart, disease, peripheral vascular disease, and a number of potential coronary heart disease risk factors including medical history, health practice, social history, diet, glycosylated hemoglobin, insulin, proinsulin, c-peptide, glucose, anthrometric measurements, lipids, and computed tomography on the thorax, abdomen, and thigh.


Ages Eligible for Study:   45 Years to 74 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria
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Please refer to this study by its identifier: NCT00005365

Sponsors and Collaborators
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Wilfred Fujimoto University of Washington
  More Information

Publications: Identifier: NCT00005365     History of Changes
Other Study ID Numbers: 4252
R01HL049293 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: February 8, 2016

Additional relevant MeSH terms:
Diabetes Mellitus
Cardiovascular Diseases
Heart Diseases
Metabolic Syndrome X
Insulin Resistance
Coronary Artery Disease
Myocardial Ischemia
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Nutrition Disorders
Body Weight
Signs and Symptoms
Arterial Occlusive Diseases
Vascular Diseases
Coronary Disease processed this record on August 18, 2017