Now Available: Final Rule for FDAAA 801 and NIH Policy on Clinical Trial Reporting

Gender Differences in Familial Risk

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Virginia Commonwealth University Identifier:
First received: May 25, 2000
Last updated: February 29, 2016
Last verified: February 2016
To develop, test, and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences.

Cardiovascular Diseases
Heart Diseases

Study Type: Observational

Further study details as provided by Virginia Commonwealth University:

Study Start Date: February 1993
Estimated Study Completion Date: January 1996
Detailed Description:


Models were developed which allowed for sex difference in the expression of autosomal polygenes, differences in the impact of the paternal and maternal environment on male and female offspring, and for the complex consequences of assortative mating on the correlations among loci and between genes and environment. Computer simulations were used to decide which kinds of gender-dependent effects could be resolved with particular constellations of relatives, and to address problems of power and bias resulting from errors of model-specification. The methods developed were applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight, body-mass index, family history of CV disease, smoking, alcohol consumption, exercise, diet, psychosocial variables and lifestyle.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

Publications: Identifier: NCT00005355     History of Changes
Other Study ID Numbers: 4241  R01HL048148 
Study First Received: May 25, 2000
Last Updated: February 29, 2016
Health Authority: United States: Federal Government

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases processed this record on October 25, 2016