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Gender Differences in Familial Risk

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Virginia Commonwealth University Identifier:
First received: May 25, 2000
Last updated: February 29, 2016
Last verified: February 2016
To develop, test, and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences.

Cardiovascular Diseases Heart Diseases

Study Type: Observational

Further study details as provided by Virginia Commonwealth University:

Study Start Date: February 1993
Estimated Study Completion Date: January 1996
Detailed Description:


Models were developed which allowed for sex difference in the expression of autosomal polygenes, differences in the impact of the paternal and maternal environment on male and female offspring, and for the complex consequences of assortative mating on the correlations among loci and between genes and environment. Computer simulations were used to decide which kinds of gender-dependent effects could be resolved with particular constellations of relatives, and to address problems of power and bias resulting from errors of model-specification. The methods developed were applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight, body-mass index, family history of CV disease, smoking, alcohol consumption, exercise, diet, psychosocial variables and lifestyle.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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No Contacts or Locations Provided
  More Information

Publications: Identifier: NCT00005355     History of Changes
Other Study ID Numbers: 4241
R01HL048148 ( US NIH Grant/Contract Award Number )
Study First Received: May 25, 2000
Last Updated: February 29, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases processed this record on June 22, 2017