Gender Differences in Familial Risk

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005355
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : March 2, 2016
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Virginia Commonwealth University

Brief Summary:
To develop, test, and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences.

Condition or disease
Cardiovascular Diseases Heart Diseases

Detailed Description:


Models were developed which allowed for sex difference in the expression of autosomal polygenes, differences in the impact of the paternal and maternal environment on male and female offspring, and for the complex consequences of assortative mating on the correlations among loci and between genes and environment. Computer simulations were used to decide which kinds of gender-dependent effects could be resolved with particular constellations of relatives, and to address problems of power and bias resulting from errors of model-specification. The methods developed were applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight, body-mass index, family history of CV disease, smoking, alcohol consumption, exercise, diet, psychosocial variables and lifestyle.

Study Type : Observational
Study Start Date : February 1993
Study Completion Date : January 1996

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

Publications: Identifier: NCT00005355     History of Changes
Other Study ID Numbers: 4241
R01HL048148 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: March 2, 2016
Last Verified: February 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases