Chronic Stress as a Risk Factor in the Etiology of Coronary Heart Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005352
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : February 18, 2016
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To conduct a prospective, longitudinal, analysis of the psychophysiological effects of chronic exposure to environmental stress. The study took advantage of a unique, naturally occurring experiment caused by the relocation of a major international airport.

Condition or disease
Cardiovascular Diseases Coronary Disease Heart Diseases

Detailed Description:


Studies were conducted on blood pressure and the neuroendocrine effects of noise resulting from the relocation of the Munich International Airport. At the former airport site the investigators monitored people exposed to high levels of noise and then tracked these same individuals as their ambient environment became normal following the shutdown of the airport. At the new airport site, the opposite situation occurred: Individuals living in normal, quiet ambient conditions became exposed to loud aircraft noise. At both sites, control groups were formed who were not exposed to aircraft noise. The study piggybacked onto a German sponsored grant. NIH funds covered the costs of cardiovascular and psycho-physiological data analysis. Measures included biochemical assays of chronic neuroendocrine markers of stress, resting blood pressure, and reactivity of blood pressure during cognitive tasks. Perceptions of community noise levels were also assessed as possible mediators of the stressful effects of chronic exposure to ambient, environmental noise.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Study Type : Observational
Study Start Date : September 1992
Actual Study Completion Date : August 1996

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Diseases

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00005352

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Gary Evans Cornell University