Psychosocial Factors and Cardiovascular Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005315
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : March 8, 2013
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Columbia University

Brief Summary:
To evaluate the role of psychosocial factors in the development of hypertension and cardiovascular disease.

Condition or disease
Cardiovascular Diseases Heart Diseases Hypertension

Detailed Description:


The studies had several interrelated themes. One was to explore the relationships between environmental stress and blood pressure over a range of time courses, with acute laboratory studies at one extreme, and long- term prospective studies at the other. The basic model of stress included three elements: the objective nature of the stressor, the individual's perception of it, and his or her physiological susceptibility. This model incorporated elements of the Karasek Job Strain model and the Frankenhaueser effort-distress model, with two components corresponding to demand and control. A third dimension was social support. These models were tested under both laboratory and field conditions. Blood pressure was the main dependent variable, together with structural changes in the heart and carotid arteries. Five projects were included. Project l evaluated the ability of ambulatory blood pressure, and blood pressure variability, to predict cardiovascular morbidity, and also included a cross-sectional study comparing the relationships between blood pressure and target organ damage in Black and white individuals. The hypothesis that white coat hypertension is a condition associated with lower risk than sustained hypertension was also tested. Project 2 prospectively evaluated the effects of job strain and social support on blood pressure and other outcome variables in a working population. Project 3 studied psychosocial and hormonal factors influencing diurnal variations of blood pressure in women, including the changes associated with menstruation and the menopause. Project 4 assessed within-subject changes of blood pressure in subjects exposed to changing levels of occupational stress over two months. Project 5 examined the conceptual models of job strain, social support, and white coat hypertension in controlled laboratory conditions.

The study was renewed in FY 1998 and in FY 2003 to continue follow-up and analysis.

Study Type : Observational
Official Title: Psychosocial Factors and Cardiovascular Disease
Study Start Date : September 1993
Actual Primary Completion Date : August 2008
Actual Study Completion Date : August 2008

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00005315

Sponsors and Collaborators
Columbia University
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Joseph Schwartz, PhD Columbia University


Responsible Party: Columbia University Identifier: NCT00005315     History of Changes
Other Study ID Numbers: 4078
5P01HL047540 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: March 8, 2013
Last Verified: August 2008

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases