Behavioral Factors in Coronary Heart Disease

This study has been completed.
Sponsor:
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Duke University
ClinicalTrials.gov Identifier:
NCT00005314
First received: May 25, 2000
Last updated: March 12, 2015
Last verified: February 2015
  Purpose
To elucidate the role of biobehavioral factors in the etiology, pathogenesis and course of coronary heart disease (CHD) and to use this knowledge to devise more effective prevention, treatment and rehabilitation approaches.

Condition
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Metabolic Syndrome X

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Cross-Sectional

Resource links provided by NLM:


Further study details as provided by Duke University:

Primary Outcome Measures:
  • Manifestations of the metabolic syndrome [ Time Frame: 6 weeks ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA
Urine and plasma samples and extracted DNA are retained

Enrollment: 694
Study Start Date: July 1986
Study Completion Date: December 2008
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   22 Years to 45 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy normal volunteers
Criteria
We will recruit 500 probands (half African American and half Caucasian, half men and half women, and half scoring in the top and half in the bottom 20% on an established hostility scale), at least one sibling from each proband and as many parents as possible.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00005314

Sponsors and Collaborators
Duke University
National Heart, Lung, and Blood Institute (NHLBI)
Investigators
Principal Investigator: Redford B Williams, M.D. Duke University
  More Information

Publications:

Responsible Party: Duke University
ClinicalTrials.gov Identifier: NCT00005314     History of Changes
Other Study ID Numbers: Pro00008338  P01HL036587 
Study First Received: May 25, 2000
Last Updated: March 12, 2015
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Metabolic Syndrome X
Coronary Disease
Coronary Artery Disease
Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases
Myocardial Ischemia
Vascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases

ClinicalTrials.gov processed this record on August 28, 2016