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Sleep Apnea: Age Effects On Prevalence and Natural History

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ClinicalTrials.gov Identifier: NCT00005296
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : June 24, 2005
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To identify the prevalence of sleep apnea in men and its relationship to age, assess the natural history of the disorder, and predict those men at risk.

Condition or disease
Lung Diseases Sleep Apnea Syndromes

Detailed Description:


Sleep apnea is potentially a life-threatening disorder commonly associated with the aging process. Often sleep apnea is accompanied by considerable morbidity for both physical and mental health; the associated excessive daytime sleepiness, cardiovascular abnormalities, and cognitive impairment impact greatly on daytime functioning. In 1990, the prevalence of sleep apnea in the general population was undetermined, and there was much speculation regarding its natural history.


For the prevalence study, 4,364 randomly-sampled men selected from the general population and stratified by age were evaluated for risk factors for sleep apnea. A total of 741 men found to be at risk were evaluated in the sleep laboratory to determine the degree, if any, of sleep apnea or sleep disordered breathing. Prior to recording subjects in the sleep laboratory, a thorough history was obtained from each subject and a physical examination completed. All men entering into the first four years of the prevalence portion of the study who were found to have sleep apnea or sleep disordered breathing were reevaluated yearly over a five year period in the natural history part of the study. The natural history portion also included 150 men previously studied in the sleep laboratory for apnea but who were not part of the random sample of 4,000 and who were not part of the prevalence study.

Study Type : Observational
Study Start Date : January 1990
Estimated Study Completion Date : December 1994

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sleep Apnea
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

ClinicalTrials.gov Identifier: NCT00005296     History of Changes
Other Study ID Numbers: 2019
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: June 24, 2005
Last Verified: August 2000

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Lung Diseases
Respiration Disorders
Respiratory Tract Diseases
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases