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Idiopathic Pulmonary Fibrosis: a Case-control Study

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of New Mexico Identifier:
First received: May 25, 2000
Last updated: January 14, 2016
Last verified: January 2016
To determine risk factors for idiopathic pulmonary fibrosis.

Lung Diseases Pulmonary Fibrosis Lung Diseases, Interstitial

Study Type: Observational

Resource links provided by NLM:

Further study details as provided by University of New Mexico:

Study Start Date: July 1989
Estimated Study Completion Date: June 1995
Detailed Description:


Idiopathic pulmonary fibrosis is a progressive and generally fatal disease that causes fibrosis of the pulmonary interstitium. While many environmental agents cause diseases clinically similar, the etiology of idiopathic pulmonary fibrosis suggests that environmental agents could incite the tissue injury that results in the disease; furthermore, host characteristics could have an important role in determining the magnitude of the host response to the agent initiating injury.


In this case control study, cases were ascertained at the multiple collaborating centers and controls were identified by telephone screening. A telephone interview was conducted to collect information needed to test hypotheses concerning cigarette smoking, occupational exposure, indoor exposures, other environmental factors, and host factors. To limit disease misclassification, two pathologists experienced with interstitial diseases of the lung reviewed histopathological material from all cases to exclude entities other than interstitial lung fibrosis and to fully characterize the cases clinically. The mortality of this large series of cases was also described.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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  More Information

Publications: Identifier: NCT00005295     History of Changes
Other Study ID Numbers: 2018
R01HL043153 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: January 14, 2016

Additional relevant MeSH terms:
Lung Diseases
Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Lung Diseases, Interstitial
Pathologic Processes
Respiratory Tract Diseases
Idiopathic Interstitial Pneumonias processed this record on September 21, 2017