Idiopathic Pulmonary Fibrosis: a Case-control Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005295
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : January 15, 2016
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of New Mexico

Brief Summary:
To determine risk factors for idiopathic pulmonary fibrosis.

Condition or disease
Lung Diseases Pulmonary Fibrosis Lung Diseases, Interstitial

Detailed Description:


Idiopathic pulmonary fibrosis is a progressive and generally fatal disease that causes fibrosis of the pulmonary interstitium. While many environmental agents cause diseases clinically similar, the etiology of idiopathic pulmonary fibrosis suggests that environmental agents could incite the tissue injury that results in the disease; furthermore, host characteristics could have an important role in determining the magnitude of the host response to the agent initiating injury.


In this case control study, cases were ascertained at the multiple collaborating centers and controls were identified by telephone screening. A telephone interview was conducted to collect information needed to test hypotheses concerning cigarette smoking, occupational exposure, indoor exposures, other environmental factors, and host factors. To limit disease misclassification, two pathologists experienced with interstitial diseases of the lung reviewed histopathological material from all cases to exclude entities other than interstitial lung fibrosis and to fully characterize the cases clinically. The mortality of this large series of cases was also described.

Study Type : Observational
Study Start Date : July 1989
Study Completion Date : June 1995

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria