Late Sequelae of Bronchopulmonary Dysplasia
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ClinicalTrials.gov Identifier: NCT00005287 |
Recruitment Status
:
Completed
First Posted
: May 26, 2000
Last Update Posted
: January 12, 2016
|
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Condition or disease |
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Lung Diseases Bronchopulmonary Dysplasia |
BACKGROUND:
Eleven to 22 percent of prematurely born human infants with Respiratory Distress Syndrome (RDS) treated with artificial ventilation and supplemental oxygen therapy, develop a severe chronic lung disease called bronchopulmonary dysplasia. While many children who had BPD are asymptomatic by three years of age, some can have respiratory symptoms and abnormal pulmonary function tests at nine years of age. The hypothesis tested in this study is that abnormalities of pulmonary function seen in infants with BPD can persist into adolescence, even in asymptomatic children and young adults.
DESIGN NARRATIVE:
A detailed interval pulmonary history was taken. Pulmonary abnormalities were determined by pulmonary angiography and lateral chest x-ray and pulmonary function tests for small airway obstruction, reversible bronchial hyperreactivity, distribution of ventilation, air trapping and hyperinflation, residual interstitial disease or edema, vascular bed loss, and gas exchange. Right and left ventricular hypertrophy were evaluated by electrocardiogram. Elevated right ventricular pressure was estimated by echocardiography with doppler ultrasound. The atopic status of the children was determined. Other abnormalities, including growth retardation, developmental delay, hearing loss, retrolental fibroplasia, and neurologic disability seen in BPD were assessed by history and physical examination.
Study Type : | Observational |
Study Start Date : | July 1986 |
Study Completion Date : | June 1989 |

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Ages Eligible for Study: | up to 100 Years (Child, Adult, Senior) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Publications:
ClinicalTrials.gov Identifier: | NCT00005287 History of Changes |
Other Study ID Numbers: |
2008 R01HL036796 ( U.S. NIH Grant/Contract ) |
First Posted: | May 26, 2000 Key Record Dates |
Last Update Posted: | January 12, 2016 |
Last Verified: | January 2016 |
Additional relevant MeSH terms:
Lung Diseases Bronchopulmonary Dysplasia Respiratory Tract Diseases Ventilator-Induced Lung Injury |
Lung Injury Infant, Premature, Diseases Infant, Newborn, Diseases |