Late Sequelae of Bronchopulmonary Dysplasia

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ClinicalTrials.gov Identifier: NCT00005287

Recruitment Status : Completed

First Posted : May 26, 2000

Last Update Posted : January 12, 2016

Sponsor:

Collaborator:

National Heart, Lung, and Blood Institute (NHLBI)

Information provided by:

Stanford University

Study Description

Brief Summary:

To measure the cardiopulmonary function in individuals who developed bronchopulmonary dysplasia (BPD) at Stanford University Medical Center from 1964-1973 and to determine the factors associated with the presence of cardiopulmonary function abnormalities in these adolescents and young adults.

Condition or disease
Lung Diseases Bronchopulmonary Dysplasia

Detailed Description:

BACKGROUND:

Eleven to 22 percent of prematurely born human infants with Respiratory Distress Syndrome (RDS) treated with artificial ventilation and supplemental oxygen therapy, develop a severe chronic lung disease called bronchopulmonary dysplasia. While many children who had BPD are asymptomatic by three years of age, some can have respiratory symptoms and abnormal pulmonary function tests at nine years of age. The hypothesis tested in this study is that abnormalities of pulmonary function seen in infants with BPD can persist into adolescence, even in asymptomatic children and young adults.

DESIGN NARRATIVE:

A detailed interval pulmonary history was taken. Pulmonary abnormalities were determined by pulmonary angiography and lateral chest x-ray and pulmonary function tests for small airway obstruction, reversible bronchial hyperreactivity, distribution of ventilation, air trapping and hyperinflation, residual interstitial disease or edema, vascular bed loss, and gas exchange. Right and left ventricular hypertrophy were evaluated by electrocardiogram. Elevated right ventricular pressure was estimated by echocardiography with doppler ultrasound. The atopic status of the children was determined. Other abnormalities, including growth retardation, developmental delay, hearing loss, retrolental fibroplasia, and neurologic disability seen in BPD were assessed by history and physical examination.

Study Design


Study Type :	Observational
Study Start Date :	July 1986
Study Completion Date :	June 1989

Resource links provided by the National Library of Medicine

Genetic and Rare Diseases Information Center resources: Bronchopulmonary Dysplasia

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:	up to 100 Years (Child, Adult, Senior)
Sexes Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

No Contacts or Locations Provided

More Information

Publications:

Northway WH Jr, Moss RB, Carlisle KB, Parker BR, Popp RL, Pitlick PT, Eichler I, Lamm RL, Brown BW Jr. Late pulmonary sequelae of bronchopulmonary dysplasia. N Engl J Med. 1990 Dec 27;323(26):1793-9.


ClinicalTrials.gov Identifier:	NCT00005287 History of Changes
Other Study ID Numbers:	2008 R01HL036796 ( U.S. NIH Grant/Contract )
First Posted:	May 26, 2000 Key Record Dates
Last Update Posted:	January 12, 2016
Last Verified:	January 2016

Additional relevant MeSH terms:


Lung Diseases Bronchopulmonary Dysplasia Respiratory Tract Diseases Ventilator-Induced Lung Injury	Lung Injury Infant, Premature, Diseases Infant, Newborn, Diseases

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