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Tucson Epidemiology Study of Chronic Obstructive Lung Diseases

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005279
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : February 29, 2016
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To determine the natural history, etiology, and interrelationships of emphysema, chronic bronchitis, asthma, and related airways obstructive diseases. Also, to determine the relationship of acute lower respiratory tract illnesses in infants and children to the development of subsequent chronic lung disorders.

Condition or disease
Asthma Bronchitis Emphysema Lung Diseases, Obstructive Chronic Obstructive Pulmonary Disease

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Study Type : Observational
Study Start Date : June 1971
Actual Study Completion Date : November 1997

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Lung Diseases

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

Burrows B (Ed): Chronic Respiratory Disease, Med Clin North Am, W.B. Saunders Co, May 1973
Burrows B: Early Detection of Airways Obstruction, Editorial. Chest, 1973
Morse JO, Lebowitz MD, Burrows B: A Community Study of the Relationship of Alpha One Antitrypsin Deficiency and Obstructive Lung Disease. (Abs) Amer Rev Respir Dis, 109:718, 1974. N Engl J Med, 292:278-281, 1975
Burrows B: Prognosis of the Bronchial and Emphysematous Types. In: Chron Obstr Lung, Stuttgart: Schattauer, pp. 171-173, 1975
Lebowitz M, Burrows B: The Tucson Epidemiology Study of Chronic Lung Disease. II. The Effects of In-Migration on Prevalence Rates of Disease. Am J Epidemiol, 102:152-163, 1975
Lebowitz M, Burrows B: The Relationship of Acute Respiratory Illness History as a Precursor of Chronic Obstructive Lung Disease. (Abs) in Proc. Soc. Epidem. Res., Am J Epidemiol, 100:511, 1974
Lebowitz M: Aerosol Usage and Respiratory Symptomatology. Arch Environ Health. (Presented at Food and Drug Administration Hearings, Washington, D.C, Dec. 16-18, 1974
Barbee R, Lebowitz MD, Morse JO, Burrows B: The Relationships of Atopy and Smoking Habits to Respiratory Disease in a General Population. (Abs) J Clin Res, 24:121A, 1976
Taussig L, Lebowitz MD: Cough and Wheeze Syndromes in Children. (abs) Am Rev Respir Dis, 113 (part 2):45, 1976
Lebowitz MD: A Critical Examination of Factorial Ecology and Social Area Analysis for Epidemiological Research. J Az Acad Sci, 12:86-90, 1977
Lebowitz MD, Johnson WM, Kaltenborn W: Coccidioidin Skin Test Reactivity and Cross-Reactivity with Histoplasmin in a Tucson Population. Coccidioidomycosis (Ajello, L, Ed.) Selected Papers from 3rd Intr. Coccidioidomycosis Symposium, Tucson, Az., Nov, 1976, Miami, Fla.: Symposia Specialists 1977
Lebowitz MD: Alcohol Consumption, Smoking and Respiratory Symptomatology. (abs) Am J Epidemiol, 106:248, 1977 (Presented at the 10th Annual Meeting Soc. Epidemiol Res., Seattle, June 16, 1977
Lebowitz MD, Knudson RJ, Armet D, Kaltenborn W, Burrows B: Longitudinal Changes in Lung Function and Respiratory Symptoms. (abs) IEA Proc, 1977, 193 (Presented at the 8th Scientific Meeting of IEA, San Juan, Puerto Rico September 1977
Lebowitz MD: Temporal Analysis of Acute Respiratory Symptoms, Aero-Allergens and Air Pollution. (abs) IEA Proc., 194 (Presented at the 8th Scientific Meeting of IEA, San Juan, Puerto Rico, September 1977
Burrows B: Course and Prognosis in Advanced Disease. In: Chronic Obstructive Pulmonary Disease, Petty T (Ed), New York: Marcel Dekker, Inc., Chapter 2, pp. 23-33, 1978
Garfield M, Sugihara S, Abraham TA, Lebowitz MD, Burrows B: Characteristics of Individuals With Rapidly Declining FEV1 Identified Within a General Population. (abs) Am Rev Respir Dis, 121(#4, part 2):138, 1980. Presented at the ATS Annual Meeting, Washington, D.C., May 21, 1980
Abraham TA, Garfield M, Sugihara S, Lebowitz MD, Burrows B: Methacholine Inhalation Challenge in Normal Individuals Using the Maximum and Partial Flow Curves With an Assessment of Diurnal Variation. (abst) Am Rev Respir Dis, 121 (#4, Part 2):53, 1980
Burrows B: Prognostic Factors in Chronic Obstructive Pulmonary Disease. Pract Cardiol, 6(10):61-69, 1980
Wagener JS, Taussig LM, Burrows B, Hernried L, Boat T: Comparison of Lung Function and Survival Patterns Between Cystic Fibrosis and Emphysema or Chronic Bronchitis Patients. Perspectives in Cystic Fibrosis, Proceedings of the 8th International Cystic Fibrosis Congress, Toronto, May 1980
Frank R, Lebowitz MD: The Risk of Staying In. (Editorial) Am Rev Respir Dis, 124:522, 1981
Lebowitz MD: Silica, Silicosis, and Lung Cancer: A Review. Ariz Med, 38(8):596-597, 1981
Landau LI, Taussig LM, Burrows B, Cline M, Lebowitz MD, Knudson R: Sex Differences in Growth Velocity of Lung Function Assessed From Longitudinal Measurements in Healthy Subjects Age 6 to 25 Years. Australian Ped J, 17(2):145, 1981
Dodge R, Burrows B: Chronic Bronchitis and Emphysema. In: Prognosis Contemporary Outcomes of Disease. (JF Fries, GE Ehrlich, Eds) Bowie, MD: Charles Press Publishers, pp. 228-231, 1981
Burrows B: Management of Chronic Obstructive Lung Disease. Drug Ther, pp. 127-133, Nov. 1981
Coaker L, Lebowitz MD, Abraham T, Garfield M, Suqihara S, Burrows B: Methacholine Challenge: The Correlation of Smoking With Airway Response in Symptomatic and Asymptomatic Subjects. Am Rev Respir Dis, 125(#4, part 2):253, 1982
Lebowitz MD, Knudson RJ, Armet D, Kaltenborn W, Burrows B: Smoking and Longitudinal Changes in Lung Function and Respiratory Symptoms. Indian J Chest Dis, Special Number: Smoking and Health, pp. 47-56, 1982
Burrows B: Irreversible Airways Obstruction and Asthma. Pract Cardiol, 8(7):69-81, 1982
Lebowitz MD, Armet DB, Knudson RJ: The Effect of Passive Smoking on Pulmonary Function in Children. Environ Internat'l, 8:371-374, 1982
Lebowitz MD: The Effects of Alcohol Ingestion on the Lung. Pract Cardiol, 8:101-104, 1982
Lebowitz M, O'Rourke M, Dodge R, Holberg C, Corman G, Hoshaw R, Pinnas J, Barbee R, Sneller M: The Adverse Health Effects of Biological Aerosols, Other Aerosols, and Microclimate Indoors on Asthmatics and Non-Asthmatics. Environ Internat'l, 8:375-380, 1982
Burrows B: The Natural History of Airflow Limitation. Med Clin North Am, pp. 2157-2162, April 1982
Burrows B: The Natural History of Airflow Limitation. Med Internat'l, 1:955-956, 1982
Lebowitz MD, Dodge R, Holberg C: The Effects of the Environment on Pulmonary Function in Children, In: Proceedings of the National Congress on Pediatric Bronchopneumonology. D. Castello (Ed), Turin: Italian Ped. Bronchopneumonal. Assn., 1982
Bloom, JW, Sugihara S, Garfield M, Abraham T, Knudson RJ: Factors Associated With Rapid Decline in Lung Function. Am Rev Respir Dis, 125:258S, 1982
Bloom J, Sugihara S, Garfield M, Abraham T, Knudson RJ: Characteristics of Individuals With Accelerated Declines in Lung Function. Chest, 85(6):18S-19S, 1983
Lebowitz MD: Temporal Analysis of Acute Respiratory Symptoms Aero-Allergens and Air Pollution. (Przeglad Lekarski) Med Review (Poland), 40:777-782, 1983
Lebowitz MD: Toxic Substances in the Atmospheric Environment: A Discussion. J Air Polln Control Assn, 33(9):832-834, 1983
Lebowitz MD, Dodge RR, Holberg CJ, Corman G, Boyer B: Daily Symptoms Related to Indoor Pollution in Adult Asthmatics and Non-Asthmatics. Am J Epidemiol, 118(3):419, 1983
Burrows B: COPD: A New Look at DX and RX of an Old Problem. Modern Med, pp. 114-126, March, 1983
Burrows B, Knudson RJ, Quan SF, Kettel LJ: Respiratory Disorders: A Pathophysiologic Approach, 2nd Ed. Revised. Chicago: Year Book Medical Publishers, Inc. 1983
Burrows B: Early Diagnosis of COPD: Value of Annual Spirometric Examination of Smokers. Pract Cardiol, 9:143-150, 1983
Burrows B: Trends in Respiratory Medicine. Todays Therapeutic Trends, 1:11-20, 1983
Lebowitz MD: Potential Respiratory Problems Within the Home Environment, In: Energy, Air Pollution and Health: Seminar Proceedings. W. Linn (Ed) New York: American Lung Association, pp. 76-87, 1983
Lebowitz MD, Waller RE, Jacobsen M, Kostrezewski J, Hasegawa Y (Eds): Guidelines on Studies in Environmental Epidemiology. (Environmental Health Criteria 27) Geneva: World Health Organization, 1983
Lebowitz MD, et al: Organization and Conduct of Studies. Chapter 5 in: Lebowitz MD, Waller RE, Jacobsen M, Kostrezewski J, Hasegawa Y, (Eds) Guidelines on Studies in Environmental Epidemiology. (Environmental Health Criteria 27) Geneva: World Health Organization, pp. 211-261, 1983
Bloom JW, Farland AM, Halonen M, Burrows B: Pneumococcus Specific IgE in Cigarette Smokers. Am Rev Respir Dis, 129(4):A191, 1984
Lebowitz MD, Knudson R, Burrows B: Risk Factors for Airway Obstructive Diseases: A Multiple Logistics Approach. Chest, 85(6):11S-12S, 1984
Bloom JW, Kaltenborn W, Paoletti P, Camilli A, Lebowitz MD: Respiratory Effects of Non-Tobacco Cigarettes. Am Rev Respir Dis, 129 (#4, Part 2):A:78, 1984
Bloom JW, Burrows B: Diseases Associated With Airflow Limitation, In: Current Pulmonology, Vol. 5 (Simmons DH, Ed) John Wiley & Sons, Inc., pp. 255-281, 1984
Burrows B: Possible Pathogenetic Mechanisms in Chronic Airflow Obstruction. Chest, 85S:13S-15S, 1984
Camilli A, Paoletti P, Lebowitz MD: Types of Occupational Exposures, Respiratory Symptoms and Lung Function. Am Rev Respir Dis, 129 (#4, part 2):A170, 1984
Dodge RR, Lebowitz MD, Barbee RA, Burrows B: Immediate Reactions to Coccidioidin and Spherulin: The Relation of Atopy to Coccidioidomycosis. In: Einstein H (Ed), Coccidioidomycosis: Proceedings of the Fourth International Conference, Washington, DC: Nat'l Foundation Infectious Diseases, 1985
Martinez F, Lebowitz MD, Taussig LM: A Longitudinal Study on the Outcome of Asthmatic Syndromes in Infancy and Childhood. Am Rev Respir Dis, 131(#4, part 2):A243, 1985
Holberg CJ, O'Rourke MK, Lebowitz MD: A Factor For All Seasons. Am Rev Respir Dis, 131 (#4, part 2):A176, 1985
Lebowitz MD: Prevalence and Natural History of Asthma. In 'Lessons From the Past' (Reed C, Ed) Bernstein IL (Ed) Guidelines for Evaluation of Nonbronchodilator Therapy of Asthma. Wash., DC: American Academy of Allergy and Immunology, pp. 8-22, 1986
Lebowitz MD: Passive Smoking and Health Effects. In IAQ, Stockholm: Liber Tryk, 6:29-32, 1986
Barbee RA: The Epidemiology of Asthma. Chapter in Monograph on Epidemiology of Allergic Diseases, Schlumberger HD (Ed). S Karger, Basel, Publisher. 1987
Lebowitz MD, Camilli AE, Bronnimann D, Quackenboss JJ: The Significance and Meaningfulness of Intraindividual Changes in Objective Test Results. In: Proceedings, Pittsburgh: APCA, (in press), 1987
Quackenboss JJ, Lebowitz MD, Camilli AE, et al: Multipollutant Interactions and Health. In ibid
Lebowitz MD, Quackenboss JJ, et al: Development of Questionnaires and Survey Instruments. In: Design and Protocol. Phila.: ASTM, (in press), 1987
Lebowitz MD: Respiratory Symptom: Concepts and Techniques for the Study of Respiratory Changes in Aging. In: Kent B and Butler RN (Eds), Human Aging Research: Concepts and Techniques. New York: Raven Press, 1988
Lebowitz MD: Prevalence and Incidence Rates of Airway Obstructive Peroblems: An International Comparison. Med Thoracica, 10:189-93, 1988
Lebowitz MD: Allergy Sufferers in the Southwest. Medical and Health Annual Chicago: Encyclopedia Britannica, pp. 274-276, 1988
Burrows B: Distribution of Allergy in the General Population. In: Bronchits IV. Proceedings Royal Van Gorcum Assen. The Netherlands. pp. 3-13, 1989
Burrows B: Allergy and Its Relationship to Asthma, Bronchial Reactivity and Chronic Airways Obstruction: An Epidemiological Perspective. In: S.T. Weiss and D. Sparrow (Eds), Airways Responsiveness and Allergy in the Development of Chronic Lung Disease. Raven Press, New York, NY, pp. 241-270, 1989
Barbee RA: Airways Responsiveness and Allergy in the Development of Chronic Lung Disease. In: Methodological Issues in the Assessment of Allergy. Edited by ST Weiss, M.D. and D Sparrow, M.D. Raven Press, New York, 1989
Burrows B: Natural History of Chronic Airflow Obstruction. In: Clinical Epidemiology of Chronic Obstructive Pulmonary Disease (Eds) M Hensley and NA Saunders. Marcel Dekker, Inc., 1989
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Strunk RC, Sieber OF Jr, Taussig LM, Gall EP: Serum Complement Depression Associated With Viral Pulmonary Illness in Cystic Fibrosis. Clin Res, XXIV, 198A, 1976
Carroll J, Taussig LM: Pulmonary Disorders. In: Immunologic Disorders in Infants and Children. Stiehm ER (Ed). W. B. Saunders Co. Edition III, 1985
Mellins R, Chernick V, Clyde W, Farrell P, Glezen WP, Rigatto H, Taussig LM: Pediatric Respiratory Disorders. NIH Publication #86-2107 August 1986
Morgan WJ: Evaluation of Forced Expiratory Flow in Infants. Proceedings of the Second State of the Art Conference on Neonatal Pulmonary Function Testing, Chicago, Perinatology Press, Ithaca, NY, 1988
Neddenriep D, Taussig LM: Infection of the Lower Respiratory Tract. In: Enchenwald, HF (Ed), Current Therapy in Pediatrics, 2, B.C. Decker Co, 1989
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Habib MP, Burrows B : Chronic Airways Obstruction: The Importance of Certain Risk Factors for Its Development. In: Current Pulmonology. DH Simmons (Ed), Year Book Medical Publishers, 1989.

Layout table for additonal information Identifier: NCT00005279    
Other Study ID Numbers: 2000
P50HL014136 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: February 29, 2016
Last Verified: May 2002
Additional relevant MeSH terms:
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Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases
Pathologic Processes
Bronchial Diseases
Respiratory Tract Infections