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Urinary Kallikrein and Hypertension: A Prospective Study

This study has been completed.
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of Utah Identifier:
First received: May 25, 2000
Last updated: January 19, 2016
Last verified: January 2016
To determine whether low total urinary kallikrein activity was prospectively associated with new hypertension onset or elevated blood pressures.

Cardiovascular Diseases Heart Diseases Hypertension

Study Type: Observational

Further study details as provided by University of Utah:

Study Start Date: July 1990
Estimated Study Completion Date: June 1993
Detailed Description:


Statistical evidence had been found for a dominant major gene segregating in large pedigrees for high urinary kallikrein levels protecting against hypertension which explained 51 percent of the variance of total urinary kallikrein (TUK). In normotensive adult and pediatric pedigree members, low urinary kallikrein activity was associated with a positive family history of hypertension, stroke, and/or coronary disease.


The presence of a previously reported dominant major gene inferred from segregation analysis of total urinary kallikrein activity (TUK) in selected pedigrees was verified on already collected frozen urine specimens. Subjects were rescreened to obtain measured nine year follow-up blood pressure data. Individuals were classified by assigned baseline TUK genotype and tested to determine whether low TUK was prospectively associated with new hypertension onset or elevated blood pressures. Because a major gene effect was implicated, available probes for the structural kallikrein gene or other related products regulating kallikrein were tested for genetic linkage to TUK levels. Correlations with over 600 variables measured at baseline in pedigrees and twins were tested to analyze the strong familiality of environment, refine the genetic analyses to better assign genotypes, and detect gene-environment interactions. All baseline variables except kallikrein, aldosterone, and prostaglandin measurements on frozen urine and follow-up blood pressure had already been collected.

TUK may be a marker for a renal, cellular or other physiological abnormality influencing both TUK expression and susceptibility to hypertension. Therefore, the relationship of TUK to urinary aldosterone, prostaglandin E excretion and already measured urinary electrolytes, plasma renin activity, and baseline and reactive blood pressures was determined. Genetic segregation analyses were performed of the urinary variables and other variables closely associated with TUK.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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  More Information

Publications: Identifier: NCT00005261     History of Changes
Other Study ID Numbers: 1145
R01HL044738 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: January 19, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Vascular Diseases processed this record on August 18, 2017