Linkage Study of Long QT Syndrome In An Amish Kindred

This study has been completed.

Sponsor:

Information provided by:

National Heart, Lung, and Blood Institute (NHLBI)

ClinicalTrials.gov Identifier:

NCT00005250

First received: May 25, 2000

Last updated: May 12, 2016

Last verified: November 2001

History of Changes

Purpose

To screen by electrocardiography the entire population of 1,400 individuals in seven Amish Mennonite communities in order to perform genetic linkage studies of long QT syndrome (LQTS).

Condition
Heart Diseases Cardiovascular Diseases Tachycardia, Ventricular Ventricular Fibrillation Long QT Syndrome


Study Type:	Observational

Resource links provided by NLM:

Genetics Home Reference related topics: Andersen-Tawil syndrome Jervell and Lange-Nielsen syndrome Romano-Ward syndrome catecholaminergic polymorphic ventricular tachycardia

Genetic and Rare Diseases Information Center resources: Paroxysmal Ventricular Fibrillation

U.S. FDA Resources

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):


Study Start Date:	January 1990
Study Completion Date:	December 1992

Detailed Description:

BACKGROUND:

LQTS is a severe heart disorder leading to sudden death due to ventricular tachycardia or ventricular fibrillation. The syndrome segregated as a Mendelian recessive in the highly inbred population under study and resulted in the sudden death of several members of the population.

DESIGN NARRATIVE:

The entire population was screened to identify cases of LQTS. In addition, 29 obligate heterozygotes were studied by 24-hour Holter monitoring to determine whether these gene carriers had any subtle phenotypes. The data were subjected to complex segregation and linkage analysis to establish the mode of inheritance and penetrance of LQTS.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Eligibility


Ages Eligible for Study:	up to 100 Years (Child, Adult, Senior)
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

No eligibility criteria

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided

More Information


ClinicalTrials.gov Identifier:	NCT00005250 History of Changes
Other Study ID Numbers:	1132 R01HL041035
Study First Received:	May 25, 2000
Last Updated:	May 12, 2016
Health Authority:	United States: Federal Government

Additional relevant MeSH terms:


Syndrome Cardiovascular Diseases Heart Diseases Tachycardia Ventricular Fibrillation Long QT Syndrome Tachycardia, Ventricular	Disease Pathologic Processes Arrhythmias, Cardiac Heart Defects, Congenital Cardiovascular Abnormalities Congenital Abnormalities

ClinicalTrials.gov processed this record on September 26, 2016

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