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Trial record 29 of 74 for:    "Andersen-Tawil syndrome" OR "Long QT Syndrome"

Long QT Syndrome-Population Genetics and Cardiac Studies (LQTS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005176
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : October 22, 2015
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Arthur J. Moss, University of Rochester

Brief Summary:
To investigate the clinical, genetic and cardiologic aspects of the Long QT Syndrome, a predominantly hereditary disease with episodic malignant arrhythmias and sudden death, and a demonstrated gene linkage in a large pedigree.

Condition or disease
Cardiovascular Diseases Heart Diseases Ventricular Arrhythmia Long QT Syndrome

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Study Type : Observational
Actual Enrollment : 2125 participants
Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Long QT Syndrome-Population Genetics and Cardiac Studies
Study Start Date : August 1985
Actual Primary Completion Date : April 2013
Actual Study Completion Date : April 2013

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. None. This is an observational study. [ Time Frame: By study end ]

Biospecimen Retention:   Samples With DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
As of the 2013 closeout report, 1329 probands with clinical dx of LQTS and members of their extended families have been enrolled in the LQTS Registry. By ECG classification, this includes 3420 probands and affected family members, 3533 unaffected family members, and 2105 family members with borderline QTc. Of those, 2125 have had mutations identified.
Probands are required to have clinical dx of LQTS. Family members are also invited to participate regardless of their dx.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00005176

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United States, New York
University of Rochester
Rochester, New York, United States, 14642
Sponsors and Collaborators
University of Rochester
National Heart, Lung, and Blood Institute (NHLBI)
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Principal Investigator: Arthur Moss University of Rochester

Weitkamp LR, Moss AJ: The Long QT (Romano-Ward) Syndrome Locus, LQT, is Probably Linked to the HLA Loci. Cytogenet Cell Genet, 40:775, 1985
Locati E, Schwartz PJ, Moss AJ, Crampton RS: Long-Term Survival After Left Cervico-Thoracic Sympathectomy in High Risk Long QT Syndrome Patients With Refractory Ventricular Arrhythmias. J Am Coll Cardiol, 7:234A, 1986
Moss AJ. Prolonged QT-Interval Syndromes. JAMA, 256:2985-2987, 1986. (Published erratum appears in JAMA, 257(4):487, 1987

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Responsible Party: Arthur J. Moss, Professor, University of Rochester Identifier: NCT00005176     History of Changes
Other Study ID Numbers: 1053
R01HL033843-16 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: October 22, 2015
Last Verified: October 2015

Additional relevant MeSH terms:
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Long QT Syndrome
Cardiovascular Diseases
Heart Diseases
Pathologic Processes
Arrhythmias, Cardiac
Cardiac Conduction System Disease
Heart Defects, Congenital
Cardiovascular Abnormalities
Congenital Abnormalities