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Coronary Heart Disease Risk Factors in Upwardly Mobile Blacks and Whites

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: May 25, 2000
Last updated: February 17, 2016
Last verified: May 2000
To evaluate the relation between blood pressure and socioeconomic status, electrolyte intake, obesity and psychosocial factors in Black and white students. Also, to compare blood pressure, cardiovascular risk factors, sodium and potassium excretion in United States Blacks with West African Blacks.

Cardiovascular Diseases Coronary Disease Hypertension Heart Diseases Obesity

Study Type: Observational

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: July 1985
Study Completion Date: June 1990
Detailed Description:


Hypertension related diseases are major causes of morbidity and mortality among United States Blacks. Among Blacks and whites, lower levels of education are associated with higher levels of blood pressure, stroke, and coronary heart disease mortality. High levels of blood pressure in United States Blacks compared to United States whites persist even after controlling for education. Furthermore, it has been demonstrated that individuals living in the southeastern part of the United States continue to have higher stroke and coronary heart disease mortality rates than those living in most other areas of the United States. The number of upwardly mobile Blacks, based on education and occupation, has been increasing in the United States yet relatively little is known about the relationships of improvements in socioeconomic status and cardiovascular risk factors, particularly blood pressure. In Africa, for over four decades, hypertension has been regarded as a rare disease among the Black Africans. However, recent evidence from hospital and community based populations suggests that hypertension is the most prevalent cardiovascular disease among Africans and constitutes a major public health problem, particularly in West Africa. Furthermore, stroke is an increasing health problem.


In this longitudinal study, the United States students were recruited and followed annually for three years. The African students were followed for two years. At the initial clinic visit blood pressure, heart rate and anthropometric measurements were obtained and questionnaires completed concerning socioeconomic status, family and medical history, dietary practices, and smoking and drinking habits. One out of every four students had blood pressure measurements reassessed. Each participant collected an overnight urine sample for analysis of sodium and potassium. Fifty percent of the population wore a physical activity monitor for two days. Approximately ten percent of the students' families were studied to validate the hypertensive status and medical history of the parent as reported by the students and to assess known cardiovascular risk factors including obesity, smoking, alcohol intake, physical activity, and behavioral factors. Univariate analyses were conducted to assess the association between the dependent variable of blood pressure and each of the independent variables including age, body mass index, height, sodium and potassium. T-tests were used to analyze the dichotomous variables such as sex, race, and geographic location. Stratification was used to examine blood pressure levels for Blacks and whites by socioeconomic status. Multiple regression models were used to determine whether physiological or psychosocial variables were more predictive of cardiovascular risk.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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  More Information

Publications: Identifier: NCT00005175     History of Changes
Other Study ID Numbers: 1052
R29HL039788 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: February 17, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases processed this record on August 18, 2017