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Charleston Heart Study - Predictors of Coronary Disease in Blacks

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: May 25, 2000
Last updated: February 17, 2016
Last verified: April 2000
To examine the role of isolated systolic hypertension and other predictors of all-cause and coronary heart disease mortality in elderly Blacks and whites of the Charleston Heart Study cohort of 1960 and to compare and pool those findings with the Evans County Heart Study findings in order to develop a logistic risk function for Blacks. Also, to identify predictors of physical functioning in older Blacks and whites and to prepare rosters of the off-spring of the Charleston cohort for future studies of genetic/familial influences on cardiovascular disease.

Cardiovascular Diseases Coronary Disease Hypertension Heart Diseases

Study Type: Observational

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: January 1984
Study Completion Date: March 1995
Detailed Description:


Coronary heart disease is the leading cause of death among United States Blacks, where coronary heart disease mortality rates are among the highest in the world. There has been a marked decline in coronary heart disease mortality among Blacks in the United States including South Carolina since 1968 for reasons not well explained, although hypertension control probably has contributed to the decline. In spite of this decline, evidence emerged that fatal and non-fatal coronary heart disease rates in Blacks exceeds those of whites. Charleston Heart Study data showed that coronary heart disease cumulative survival probabilities for Black men were lower than white men during the first 20 years of the 25 year observation period. A secular trend manifested itself with relatively higher rates in Blacks but in any event, there was evidence that coronary disease was a major threat to Blacks.

The Charleston Heart Study was initiated in 1960. Randomly selected Black and white men and women 35 years of age and over were examined to obtain details concerning angina, myocardial infarction, hypertension, smoking, blood pressure, height, weight, and serum cholesterol levels. The total cohort was 2,283 persons. The last screening of the cohort was in 1974-1975 until the this study which started in 1984.

Over one half the Blacks in the United States live in the South and the Charleston Heart Study offered the opportunity to study disease and disability status of elderly Blacks, in an environment that included urban and rural residents.


In 1984-1985 a 25 year follow-up was conducted on the original Charleston Heart Study cohort. The vital status of 98 percent of the 1960 cohort was ascertained. Ninety-three percent of the survivors were revisited, interviewed, and measured for blood pressure, weight, and height. The interaction of socioeconomic status, type A behavior and John Henry behavior scores were tested. All-cause and coronary heart disease mortality were determined.

In 1987-1988 approximately 1,300 survivors were recalled for measurements of functional and cognitive status using the Framingham Functional Disability Questionnaire so that comparisons of results from Charleston and Framingham could be made. Measurements were made of blood pressure, height, weight, and heart function by auscultation, ECG, and echocardiography. Lipoproteins, glucose, and other biochemical parameters were assessed. The biomedical and sociodemographic determinants of long-term survival in Black men and women were quantified and compared with those of whites. The risk factor significance of Minnesota-coded ECG abnormalities in Blacks versus whites were identified and quantified. Familial aggregation of risk factors and potential causes of obesity were assessed.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.


Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
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No Contacts or Locations Provided
  More Information

Keil JE, Gazes PC, LoadHolt CB, Gross AJ, Sutherland S, Tyroler HA, Knowes M, Rust PF: Coronary Heart Disease and Its Predictors in Charleston, South Carolina Women. In: Coronary Heart Disease in Women. Eaker E et al (Eds). Haymarket Doyma, Inc., New York, N.Y., 1987 Identifier: NCT00005165     History of Changes
Other Study ID Numbers: 1038
R01HL031397 ( U.S. NIH Grant/Contract )
Study First Received: May 25, 2000
Last Updated: February 17, 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases processed this record on September 19, 2017