Longitudinal Twin Study - Cohort Study of Blood Pressure

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005161
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : March 8, 2016
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
Virginia Commonwealth University

Brief Summary:
To analyze the genetic and environmental contributions of juvenile hemodynamic determinants of blood pressure, including cardiac output and systemic vascular pressure, to adult cardiovascular risk.

Condition or disease
Cardiovascular Diseases Heart Diseases Hypertension

Detailed Description:


Identifying individuals at a young age who are at risk for future development of hypertension in adult life is a public health issue of great importance. The imperfect nature of blood pressure tracking throughout childhood and adolescence, and the fact that the genes which determine blood pressure in childhood may not be the same ones which operate in adulthood make it clear that improved predicting models are needed. The twin-parent study design allowed testing more subtle genetic and environmental hypotheses than was possible with nuclear families or twins alone. The longitudinal component permitted an analysis of developmental changes in the genetic expression of the hemodynamic determinants of blood pressure. The inclusion of unlike sex twins permitted an analysis of the consistency of genetic and environmental effects across the sexes.


The longitudinal comparison of the cardiovascular responses of adolescent twins and their parents was initialed in 1983. Three cohorts of twin families were enrolled, each cohort beginning 18 months apart. Both monozygotic and dizygotic twins were included. Variables measured included demographics, family history, personality, blood pressure, anthropometry, stage of puberty, dynamic exercise, isometric exercise, psychological stress, echocardiography, genotyping, and lipid profiles. Each cohort revisited every 18 months.

A fourth cohort of 330 preadolescent twin pairs stratified by sex and zygosity was recruited from an established population-based twin registry. The hemodynamic determinants of blood pressure were assessed by non-invasive measurements of cardiac function including echocardiography and response to isometric and dynamic exercise. Zygosity was determined by questionnaire and confirmed by dermatoglyphic analysis and blood group tests. Anthropometric and hemodynamic measurements in the parents were compared to those in the children. The study included up to five sets of longitudinal measurements, thereby permitting an evaluation of whether the same or different genes operated at different ages encompassing pre-puberty, puberty, and post-puberty.

Study Type : Observational
Study Start Date : August 1983
Study Completion Date : July 1993

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 100 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

Schieken RM: Exercise Study of Blood Pressure: A Predictor of Future Hypertension? In: NHLBI Workshop on Juvenile Hypertension, Loggie JHM, Horan M, Gruskin AB, et al (Eds.), Biomedical Information Corporation, NY, NY, 1984
Schieken RM: Children's Blood Pressure. Report of 8th Ross Conference on Pediatric Research, Columbus Ohio: Ross Laboratories, 1985
Eaves LJ, Hewitt JK, Heath AC: The Quantitative Study of Human Developmental Change: A Model and its Limitations. 2nd International Conference on Quantitative Genetics, Sinauer Associates, 1988 Identifier: NCT00005161     History of Changes
Other Study ID Numbers: 1033
R01HL031010 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: March 8, 2016
Last Verified: March 2016

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases