High Blood Pressure in the Young

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005138
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : May 13, 2016
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)

Brief Summary:
To continue a longitudinal study of blood pressure and blood pressure correlates in a population of 1,140 young adults, first seen in 1973 as adolescents, aged 14-19 years.

Condition or disease
Cardiovascular Diseases Heart Diseases Hypertension

Detailed Description:


This study was funded in response to a Request for Application issued in 1975 on High Blood Pressure in the Young. The program on High Blood Pressure in the Young grew out of an awareness that adult hypertension might have its origins in adolescence or even in childhood or infancy. In 1975 NHLBI was supporting little research, except for the Specialized Centers of Research, in identifying the precursors of high blood pressure operating at an early age. Sixteen grants were funded through the program. The program was concluded in 1978 but Dr. Kotchen's grant was renewed as a regular research grant. A second population group was followed in the grant period. From an original population of 409 pregnant, nulliparous adolescents aged 12-18 who had enrolled in the University of Kentucky Young Mothers Program between 1971-1974, 70 were diagnosed as having hypertension during the third trimester of pregnancy. These 70 women plus a control group of 54 normotensive women from the same population were studied as were their children. Blood pressures were measured in young mothers at 3-6 years and at 6-9 years after their first pregnancy. Women with a history of hypertension during pregnancy were heavier, maintained higher blood pressure and had a greater incidence of hypertension in subsequent pregnancies. At the second follow-up, systolic blood pressure and body weight of male children born to hypertensive women were greater than those in males born to normotensive women. Blood pressures of female children of the two groups of mothers did not differ.


In 1973 standardized blood pressure, height, and weight were measured in all 14-19 year old students of Bourbon County High School in Kentucky. Additional information collected included age, date of birth, sex, and race. In 1978 a five year follow-up study was undertaken of all adolescents 14-15 years old at the time of the initial survey and of selected 16-19 year olds who were in the high, intermediate, and low ranges of the blood pressure distributions. Follow-up measurements included weight, height, and blood pressure in all subjects, and sodium excretion, serum cholesterol, glucose, triglycerides, exercise, and uric acid concentrations, electrocardiograms, and echocardiograms in the older group. In 1984 the follow-up also included information on socioeconomic variables, medical and family histories, smoking, exercise, life events, coronary-prone behavior, and anxiety. Plasma renin activity and plasma aldosterone were measured before and after treadmill exercise in those young adults with relatively high and relatively low blood pressures to determine if the renin-aldosterone axis is suppressed before the appearance of hypertension. Studies were continued on physiologic, psychosocial, and behavioral risk factors for hypertension, age-related trends in cardiovascular risk factors over time, correlates of elevated blood pressure, and the early cardiac consequences of high blood pressure.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Study Type : Observational
Study Start Date : June 1976
Actual Study Completion Date : June 1989

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   up to 100 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria

High Blood Pressure in the Young: Kotchen TA, Havlik R (Eds). Hypertension, (Suppl 1) Part 2, p 134-135, 1980
Kotchen TA, Kotchen JM: Clinical Approaches to High Blood Pressure in the Young. Cardiovasc Rev & Reports, 1:53-57, 1980
Kotchen JM, Kotchen TA: Correlates of High Blood Pressure in Adolescents. In: High Blood Pressure in the Young and Old. Proceedings of the Sixth Hahnemann International Symposium. Onesti G, Kim K (Eds), Grune & Stratton, p 173-182, 1981 Identifier: NCT00005138     History of Changes
Other Study ID Numbers: 1009
R01HL019956 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: May 13, 2016
Last Verified: May 2000

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases