Heritage Study--Genetics, Exercise and Risk Factors (HERITAGE)
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|ClinicalTrials.gov Identifier: NCT00005137|
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : May 29, 2014
|Condition or disease||Intervention/treatment||Phase|
|Cardiovascular Diseases Heart Diseases Diabetes Mellitus, Non-insulin Dependent Diabetes Mellitus||Other: exercise program||Not Applicable|
This research should increase our understanding of human variation, the genetics of adaptation to exercise-training and of the concomitant changes in cardiovascular disease and diabetes risk factors.
A total of 742 sedentary subjects were recruited, initially tested, exercise-trained in the laboratory with the same program for 20 weeks, and re-tested. The subjects came from families of Caucasian descent with both parents and three biological adult offspring and families of African-American ancestry. Oxygen uptake, expiratory volume and respiratory exchange ratio, blood pressure, heart rate, blood lactate, glucose, glycerol and free-fatty acids, stroke volume and cardiac output were measured during exercise before and after training and maximal oxygen uptake was determined. Plasma lipids, lipoproteins and apoproteins, glucose tolerance and insulin response to an intravenous glucose load, plasma sex steroids and glucocorticoids, resting systolic and diastolic blood pressures, and body fat and regional fat distribution were also assessed. Dietary habits, level of habitual physical activity and other lifestyle components were assessed by questionnaires. Genetic analyses included the determination of the heritability level for each phenotype and its response to regular exercise, testing for the presence of paternal or maternal effects, sex-limited effects, major gene effects and segregation patterns. Multivariate genetic analyses and complex segregation analyses were used to develop hypotheses concerning the genetic basis of the response to exercise-training.
The study was renewed in September 1997 to perform analyses of the data collected under Phase I. A series of nongenetic studies were undertaken on the dataset. Physiological, behavioral, and social determinants of maximal and submaximal indicators of cardiorespiratory endurance in the sedentary state and in the response to training were investigated taking into account the contributions of age, gender, and race. Similar analyses were conducted on the cardiovascular disease and non-insulin dependent diabetes mellitus (NIDDM) risk factors monitored in the study. Genetic analyses determined the heritability levels and tested for paternal or maternal effects, major gene effects, and segregation patterns which were used to develop hypotheses concerning genetic bases of the response to endurance exercise. A panel of candidate genes were typed and used for association and linkage studies. Differential display analysis of skeletal muscle transcripts were used to identify new candidate genes for the response to endurance exercise. Finally, a genome wide search was undertaken to isolate candidate genomic regions and positional candidate genes for the response of cardiorespiratory endurance and cardiovascular and NIDDM risk factor phenotypes.
The study was renewed in 2001 for four years to continue analyses of the data.
|Study Type :||Interventional (Clinical Trial)|
|Intervention Model:||Single Group Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Health, Risk Factors, Exercise Training, and Genetics|
|Study Start Date :||July 1992|
|Actual Primary Completion Date :||August 2005|
|Actual Study Completion Date :||August 2005|
Other: exercise program
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00005137
|OverallOfficial:||Claude Bouchard||LSU Pennington Biomedical Research Center|
|OverallOfficial:||Arthur Leon||University of Minnesota - Clinical and Translational Science Institute|
|OverallOfficial:||Dabeeru Rao||Washington University School of Medicine|
|OverallOfficial:||James Skinner||Indiana University|
|OverallOfficial:||Jack Wilmore||Texas A & M Research Foundation|