Family Heart Study (FHS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00005136
Recruitment Status : Completed
First Posted : May 26, 2000
Last Update Posted : March 17, 2014
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by:
University of Minnesota - Clinical and Translational Science Institute

Brief Summary:
To identify and evaluate genetic and non-genetic determinants of coronary heart disease (CHD), atherosclerosis, and their risk factors in ongoing population-based epidemiology studies. The multicenter study was conducted in three phases which were: Phase I, the family history component: Phase II, the clinical examination and follow-up component; and Phase III, the molecular genetic and genetic epidemiology studies component.

Condition or disease
Cardiovascular Diseases Atherosclerosis Coronary Disease Heart Diseases

Detailed Description:


Advances in molecular genetics, genetic epidemiology, population genetics, and identification of new risk factors and clusters of risk factors for cardiovascular disease made 1991 an opportune time to take advantage of the extensive information about cardiovascular disease, pre-clinical atherosclerosis, and risk factors in individuals who had been examined in ongoing, state-of-the-art epidemiological studies supported by the NHLBI. By recruiting first degree relatives of random samples of such defined populations, FHS obtained information about familial aggregation, genetic and environmental contributions to variance in continuous variables, and the frequency and distribution of elevated levels of risk factors and of selected major genes in the general population.

The FHS was initiated by staff and approved by the Clinical Applications and Prevention Advisory Commitee in May, 1990. The Requests for Proposals were released in July 1991. Contracts were awarded in June, 1992.


During Phases I and II from May 1992-May 1996, probands, aged 45-69, were recruited from the Framingham Heart Study, the Utah Family Tree Study and the North Carolina and Minnesota sites of the ARIC Study, along with their relatives, for participation in the Family Heart Study. Two groups of probands were selected, either randomly or by a high family risk of CHD as calculated from data from the parent study. Additional family structure and disease history data were collected on 3,150 probands and 22,909 of their relatives. Clinical examination and follow-up of these random and high CHD risk families were conducted on a total of 1,253 families including 5,975 individuals, of whom 102 families including 265 individuals were African-American. The examinations included information on anthropometry, blood pressure, ECG, carotid ultrasound, pulmonary function, and blood chemistries. Questionnaire data included medical and reproductive histories, diet, physical activity, tobacco and alcohol consumption, education, income and psychosocial factors including hostility, social support and stress. Phases I and II included four field centers, a coordinating center, and a central blood laboratory.

In August 1996, Phase III began when cooperative agreements were awarded to a consortium of seven investigator-initiated grants to conduct molecular genetic and genetic epidemiology studies using data collected during Phases I and II. Phase III ended in July 2001. The objective of Phase III was to perform molecular genetic and genetic epidemiology studies using the extensive data on family and medical histories, risk factors, life style, blood specimens, and banked DNA previously collected by the FHS. Studies included novel molecular genetics of candidate genes and genome-wide searches with anonymous markers for the detection, mapping, and characterization of coronary heart disease and atherosclerosis genes. Genetic epidemiology analyses were conducted that contributed new information on the familial aspects of atherosclerosis and intermediate phenotypes in African Americans. Phase III also included four field centers, a central laboratory, a molecular genetics laboratory, and a coordinating center.

The study was renewed in 2001 as the Family Heart Study - Subclinical Atherosclerosis Network (FHS-SCAN) to complete analyses of genome-wide scan data and to genotype promising markers. The study expects to enroll 401 informative pedigrees (3,027 individuals) previously examined and genotyped by the NHLBI Family Heart Study to quantify coronary and aortic calcium volume in order to identify genes associated with atherosclerosis. In addition, 315 African American sibships (770 individuals) previously examined and comparably genotyped by the Hypertension Epidemiology Network (HyperGEN) will be examined at one study center to address these study questions in this minority population.

Study Type : Observational
Study Start Date : June 1992
Actual Primary Completion Date : August 2005
Actual Study Completion Date : August 2005

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
No eligibility criteria

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00005136

Sponsors and Collaborators
University of Minnesota - Clinical and Translational Science Institute
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Donna Arnett University of Minnesota - Clinical and Translational Science Institute
OverallOfficial: John Eckfeldt University of Minnesota - Clinical and Translational Science Institute
OverallOfficial: R. Ellison Boston University
OverallOfficial: Aaron Folsom University of Minnesota - Clinical and Translational Science Institute
OverallOfficial: Gerardo Heiss University of North Carolina
OverallOfficial: Steven Hunt University of Utah
OverallOfficial: Mark Leppert University of Utah
OverallOfficial: Michael Province Washington University School of Medicine
OverallOfficial: D.C. Rao Washington University School of Medicine
OverallOfficial: Roger Williams University of Utah


Publications automatically indexed to this study by Identifier (NCT Number):
Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkilä V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renström F, North KE, McKeown NM, Feitosa MF, Kanoni S, Smith CE, Garcia ME, Tiainen AM, Sonestedt E, Manichaikul A, van Rooij FJ, Dimitriou M, Raitakari O, Pankow JS, Djoussé L, Province MA, Hu FB, Lai CQ, Keller MF, Perälä MM, Rotter JI, Hofman A, Graff M, Kähönen M, Mukamal K, Johansson I, Ordovas JM, Liu Y, Männistö S, Uitterlinden AG, Deloukas P, Seppälä I, Psaty BM, Cupples LA, Borecki IB, Franks PW, Arnett DK, Nalls MA, Eriksson JG, Orho-Melander M, Franco OH, Lehtimäki T, Dedoussis GV, Meigs JB, Siscovick DS. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. Am J Clin Nutr. 2015 Nov;102(5):1266-78. doi: 10.3945/ajcn.114.101238. Epub 2015 Sep 9.
Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkilä V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC, Dhurandhar EJ, Feitosa MF, Johansson I, Khaw KT, Lohman KK, Manichaikul A, McKeown NM, Mozaffarian D, Singleton A, Stirrups K, Viikari J, Ye Z, Bandinelli S, Barroso I, Deloukas P, Forouhi NG, Hofman A, Liu Y, Lyytikäinen LP, North KE, Dimitriou M, Hallmans G, Kähönen M, Langenberg C, Ordovas JM, Uitterlinden AG, Hu FB, Kalafati IP, Raitakari O, Franco OH, Johnson A, Emilsson V, Schrack JA, Semba RD, Siscovick DS, Arnett DK, Borecki IB, Franks PW, Kritchevsky SB, Lehtimäki T, Loos RJ, Orho-Melander M, Rotter JI, Wareham NJ, Witteman JC, Ferrucci L, Dedoussis G, Cupples LA, Nettleton JA. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr. 2013 Jun;97(6):1395-402. doi: 10.3945/ajcn.112.052183. Epub 2013 May 1. Identifier: NCT00005136     History of Changes
Other Study ID Numbers: 1006
U01HL056564 ( U.S. NIH Grant/Contract )
First Posted: May 26, 2000    Key Record Dates
Last Update Posted: March 17, 2014
Last Verified: March 2014

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Arterial Occlusive Diseases
Vascular Diseases
Myocardial Ischemia