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NAS-NRC Twin Registry

This study has been completed.
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI) Identifier:
First received: May 25, 2000
Last updated: June 2, 2015
Last verified: June 2001
To continue a registry of World War II veteran twins maintained by the National Academy of Sciences-National Research Council (NAS-NRC).

Cardiovascular Diseases
Heart Diseases
Coronary Disease
Myocardial Ischemia

Study Type: Observational

Further study details as provided by National Heart, Lung, and Blood Institute (NHLBI):

Study Start Date: July 1970
Estimated Study Completion Date: September 1988
Detailed Description:


The registry of World War II veteran twins came into existence in the late 1960's through a search and link effort of state vital statistics records and Veterans Administration files through the Medical Follow-up Agency of NAS-NRC. Since that time, the registry has served as a data resource for investigators in a variety of scientific fields who want to study genetic and environmental aspects of various human characteristics. Because of the size and geographic coverage throughout the United States, the registry offers a method of recruiting sizeable numbers of twins for study even under geographic restrictions. Of special value to medical researchers is the built-in medical follow-up for morbidity and mortality through Veterans Administration insurance and benefits records. This allows researchers to gather baseline data which may be related prospectively to morbidity and mortality events.

The NHLBI has made extensive use of the World War II veteran twin registry beginning in 1969, when the NHLBI Twin Study was initiated. At that time, NHLBI used the World War II veteran twin registry to recruit a group of 514 pairs of twins in five geographic areas to participate in a study which included a battery of questionnaires and a physical examination. Since that time, a second examination and third examination of the cohort have been completed and the registry has been used to maintain contact with the twins and provide surveillance for morbidity and mortality events of the participants in the study.


Maintenance of the existing registry continued as addresses of all members were updated annually as well as morbidity and mortality data through surveillance of Veterans Administration insurance and death benefit records or through the National Death Index. All morbid events and deaths were coded by ICD codes. Support activities were provided for the NHLBI Twin Study including providing death certificates for events occurring among the 1,028 twins participating in the study and mailed questionnaire follow-up.

Although contract support ended in September, 1988, analyses of the survey and mortality data are continuing.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
No eligibility criteria
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00005125

Sponsors and Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
OverallOfficial: Zdenek Hrubec
OverallOfficial: Dennis Robinette
  More Information

Cederlof R, Epstein FH, Friberg, et al: Twin Registries in the Study of Chronic Disease. Report of an International Symposium in San Juan, Puerto Rico, 1-4 December 1969, Acta Med Scand Suppl. 523, 1971
Hrubec Z, and Sutton HE: Smoking and Health (Letter to the Editor), Lancet 2:932, 1972
Hrubec Z: Coffee Drinking and Ischaemic Heart Disease (Letter to the Editor) Lancet 1:548, 1973
Bazaral M, Orgel HA, and Hamburger RN: Genetics of IgE and Allergy: Serum IgE Levels in Twins. J Allergy Clin Immunol 54:288-304, 1974
Feinleib M, Garrison R, Borhani N, et al: Studies of Hypertension in Twins. In: Paul, Oglesby (Ed.): Epidemiology and Control of Hypertension, Second International Symposium on the Epidemiology of Hypertension, September 1974, Miami, Symposia Specialists, 1975
Taubman P: The Determinants of Earnings: Genetics, Family and Other Environments. A Study of White Male Twins. Am Economic Rev 66:858-870, 1976
Behrman J, Taubman P, and Wales T: Controlling For and Measuring the Effects of Genetics and Family Environment in Equations for Schooling and Labor Market Success. In: Taubman P (Ed.): Kinometrics: Determinants of Socioeconomic Success Within and Between Families, New York, North-Holland Publishing Company, 1977
Feinleib M, Ware JH, Garrison RJ, et al: An Analysis of Variance for Major Coronary Heart Disease Risk Factors in Twins and Their Brothers. In: Nance WE (Ed.): Twin Research. Proceedings of the Second International Congress on Twin Studies, August 29-September 1, 1977, Washington, D.C., Part C. Clinical Studies, Progress in Clinical and Biological Research Volume 24C, New York, Alan R. Liss, Inc., pp. 13-19, 1978.
Hrubec Z, and Neel JV: The National Academy of Sciences-National Research Council Twin Registry: Ten Years of Operation. In: Nance, WE (Ed.): Twin Research, Proceedings of the Second International Congress on Twin Studies, August 29-September 1, 1977, Washington, D.C., Part B. Biology and Epidemiology, Progress in Clinical and Biological Research Volume 24B, New York, Alan R. Liss, Inc., pp. 153-172, 1978
Taubman P: What We Learn from Estimating the Genetic Contribution to Inequality in Earnings: Reply, Am Econ Rev 68:970-976, 1978
Anderson RE, Hill RB, and Hrubec Z: Prospects for Pathology Studies in the NAS-NRC Twin Registry. Hum Pathol 11:403, 1980
Foch TT, and McClearn GE: Genetics, Body Weight, and Obesity. In: Stunkard, AJ (Ed.): Obesity, Philadelphia, Saunders Publishing Company, pp. 48-71, 1980
Hrubec Z: Methodologic Problems in Matched-Pair Studies Using Twins. In: Gedda L, Parisi P, and Nance WE (Eds.): Twin Research 3. Proceedings of the Third International Congress on Twin Studies, June 16-20, 1980, Jerusalem, Part C. Epidemiological and Clinical Studies, Progress in Clinical and Biological Research Volume 69C, New York, Alan R. Liss, Inc., pp. 1-7, 1981 Identifier: NCT00005125     History of Changes
Other Study ID Numbers: 904
Study First Received: May 25, 2000
Last Updated: June 2, 2015

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Pathologic Processes
Vascular Diseases
Arterial Occlusive Diseases processed this record on April 28, 2017