Treatment of Advanced AIDS Patients With Dextrin Sulfate
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ClinicalTrials.gov Identifier: NCT00004987
Verified June 2001 by NIH AIDS Clinical Trials Information Service. Recruitment status was: Active, not recruiting
The purpose of this study is to look at the safety and effectiveness of dextrin sulfate in AIDS patients who have failed conventional anti-HIV treatment.
Condition or disease
Drug: Dextrin 2-sulfate
Patients have intraperitoneal (IP) catheter placement done at study entry. Infusion with the carrier vehicle (icodextrin 4%) begins 2 weeks later, and 2 days after that, treatment with dextrin sulphate (DS) commences. DS is given three times per week. A nurse delivers initial treatments and the patient and caregiver will be trained to give subsequent treatments until DS has been given a total of 8 weeks. Patient evaluations are done regularly during treatment and observation continues for 24 weeks.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients may be eligible for this trial if they:
Have been diagnosed with AIDS and are under treatment to prevent opportunistic (AIDS-related) infection.
Have had a CD4 cell count greater than 50 microL for at least the past 3 months.
Have had a viral load of at least 50,000 copies/ml for at least the past 3 months.
Have used up all other treatment options.
Are able to understand and give written consent.
Patients may not be eligible for this trial if they:
Have been in any other study in the 6 weeks before beginning this study.
Have an active, opportunistic infection or other infection.
Have any other long-term medical condition or nervous disorder that might make it difficult for them to finish the study.